A0A3V7PAC8 · A0A3V7PAC8_SALET

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site37-39ATP (UniProtKB | ChEBI)
Binding site96-97ATP (UniProtKB | ChEBI)
Binding site131Mg2+ (UniProtKB | ChEBI)
Binding site170Mg2+ (UniProtKB | ChEBI)
Active site194
Binding site196D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site220D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site224-228D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribose phosphate diphosphokinase complex
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processphosphorylation
Biological Processpurine nucleotide biosynthetic process
Biological Processribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      BG172_03540
      , CB215_02480
      , DPP52_15015
      , E0S65_00460
      , G0D41_08070
      , G0D54_00395
      , G3331_001003
      , G4I76_001264
      , G4I81_001860
      , G4P10_002097
      , G4P17_001403
      , G4P47_000494

Organism names

Accessions

  • Primary accession
    A0A3V7PAC8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-121Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    34,216
  • Last updated
    2019-05-08 v1
  • Checksum
    4F8E29B118FD6665
MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAANNLRNSVIDEVVVCDTIPLTDEIKALPNVRTLTLSGMLAEAIRRISNEESISAMFEH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGVJG010000009
EMBL· GenBank· DDBJ
EBS3854016.1
EMBL· GenBank· DDBJ
Genomic DNA
AAIOLQ010000001
EMBL· GenBank· DDBJ
ECG4535208.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKJZK010000001
EMBL· GenBank· DDBJ
ECS5600698.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMICF010000002
EMBL· GenBank· DDBJ
EDH5772633.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAMJC010000001
EMBL· GenBank· DDBJ
HAC6863692.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAMJS010000003
EMBL· GenBank· DDBJ
HAC6947130.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARIH010000006
EMBL· GenBank· DDBJ
HAE2547254.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLT010000002
EMBL· GenBank· DDBJ
HAE6049549.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASMX010000011
EMBL· GenBank· DDBJ
HAE6181166.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASXX010000014
EMBL· GenBank· DDBJ
HAE7517687.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASYM010000004
EMBL· GenBank· DDBJ
HAE7548546.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASZT010000001
EMBL· GenBank· DDBJ
HAE7701660.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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