A0A3V2W3V5 · A0A3V2W3V5_SALHA

  • Protein
    RecBCD enzyme subunit RecB
  • Gene
    recB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.

Miscellaneous

In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site23-30ATP (UniProtKB | ChEBI)
Binding site956Mg2+ (UniProtKB | ChEBI)
Binding site1067Mg2+ (UniProtKB | ChEBI)
Active site1080For nuclease activity
Binding site1080Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentexodeoxyribonuclease V complex
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular Functiondouble-stranded DNA helicase activity
Molecular Functionexodeoxyribonuclease V activity
Molecular Functionforked DNA-dependent helicase activity
Molecular Functionfour-way junction helicase activity
Molecular Functionisomerase activity
Molecular Functionmagnesium ion binding
Molecular Functionsingle-stranded 3'-5' DNA helicase activity
Biological Processdouble-strand break repair via homologous recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RecBCD enzyme subunit RecB
  • EC number
  • Alternative names
    • DNA 3'-5' helicase subunit RecB
    • Exonuclease V subunit RecB
      (ExoV subunit RecB
      )
    • Helicase/nuclease RecBCD subunit RecB

Gene names

    • Name
      recB
    • ORF names
      A9S09_06360
      , A9T62_10775
      , AF585_14655
      , AF666_02160
      , ALY75_15525
      , APN57_18915
      , AR831_02160
      , ASH25_16795
      , AUE46_05210
      , DNL63_12580
      , DNZ98_14840
      , DOJ48_01455
      , DYN29_09200
      , E0557_11500
      , E0M77_08235
      , E2D78_01585
      , FG644_05350
      , G2993_03500
      , G3991_000718
      , G3V54_002061
      , G4G50_000859
      , G4I64_001657
      , G4L06_000948
      , G4L19_002557
      , G4Y35_003735
      , G4Y42_001443
      , GB072_07595
      , GB346_14270
      , GB349_15460
      , GBX90_07790
      , JQ05_16150
      , JQ06_11460
      , VO03_14770
      , WX36_08185

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 176241
    • 278089
    • 339499
    • 427582
    • 451957
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    A0A3V2W3V5

Proteomes

Subcellular Location

Interaction

Subunit

Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-850DNA-binding and helicase activity, interacts with RecC
Domain2-450UvrD-like helicase ATP-binding
Domain480-746UvrD-like helicase C-terminal
Region900-1181Nuclease activity, interacts with RecD and RecA

Domain

The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

Sequence similarities

Belongs to the helicase family. UvrD subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,181
  • Mass (Da)
    133,843
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    41F071A3AC59DCFA532FAAAC9DDB969E
MNDVAETLDPLRLPLTGERLIEASAGTGKTFTIAALYLRLLLGLGGSAAFPRPLTVEELLVVTFTEAATEELRGRIRSNIHELRIACLRESTDNPLYARLLEEISDKKQAAQWLLLAERQMDEAAVFTIHGFCQRMLSLNAFESGMLFEQQLIEDESLLRYQACADFWRRHCYPLPRDIAQVVFDVWKGPKALLKDIDRYLQGEAPVIKAPPSQEETLASRHEQILARINQVKQQWCEAVSELDALIESSGIDRRKFNRGNQAKWIEKITAWAQEETKNYQLPEALGKFSQRFLAERTKAGGVTPQHPLFVAIDNLLGEPLSIKDLVLTRALSEIRETVAQEKRRRGELGFDDMLSRLDTALRSESGEALAAAIRTRFPVAMIDEFQDTDPQQYRIFRRIWRHQPDTALLLIGDPKQAIYAFRGADIFTYMKARSEVSAHYTLDTNWRSAPGMVNSVNKLFSQMNDAFMFRDIPFSPVKFAPRNQSLQFKVNDAPQPAMTLWLMEGESCGSGDYQSYMAQVCATQIRDWLRAGQTGDALLTNGDSSRPVRASDISVLVRSRREAALIRDALTLLAIPSVYLSNRDSVFETLEAQEMLWVLQAVMAPERENTLRSALATSMMGLTALDIETLNNDENAWDAVVEEFDGYRQIWHKRGVMPMLRALMSARNIAENLLATAGGERRLTDILHISELLQEAGSQLESEHALVRWLAQHILEPDSNASSQQLRLESDKHLVQIVTIHKSKGLEYPLVWLPFITHFRVQDQAFYHDRHSYEAVLDLSHAEESIALAEAERLAEDLRLLYVALTRAVWHCSLGVAPLVRRRSDKKGETDVHQSALGRLLQKGEPMDAAGLRACIEALCDEDIVCRTPGNTDNDRWQIAAASHAELSARTLQRLLYDSWRVTSYSGLQQRGHSVAQDLIPRLDIDAAGVGEAAEAPAMTPHHFPRGASPGTFLHSLFEELDFTQPIDPQWVQEKLELSGFETRWEPVLTRWLDTVLHVPLNETGVSLSVLTEREKQVEMEFYLPIAQPLTAGELDALIRRYDPLSAGCPALDFMQVRGMLKGFIDLVFRYEGRYYLLDYKSNWLGEDSAAYTQTAMAAAMQAHRYDLQYQLYTLALHRYLRHRMANYDYERHFGGVIYLFLRGVDSERPQQGIFTTRPAAALINQLDDMFAGEMSEEAQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGTPS010000001
EMBL· GenBank· DDBJ
EBR8515209.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHDZG010000008
EMBL· GenBank· DDBJ
EBV0400191.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHEKO010000038
EMBL· GenBank· DDBJ
EBV1618093.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHFVA010000009
EMBL· GenBank· DDBJ
EBV6244276.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHFVH010000007
EMBL· GenBank· DDBJ
EBV6261915.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGAK010000017
EMBL· GenBank· DDBJ
EBV6844464.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGBH010000006
EMBL· GenBank· DDBJ
EBV7005795.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGIW010000001
EMBL· GenBank· DDBJ
EBV7663733.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGJI010000008
EMBL· GenBank· DDBJ
EBV7813858.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGLY010000017
EMBL· GenBank· DDBJ
EBV8260488.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGON010000007
EMBL· GenBank· DDBJ
EBV8588866.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGSF010000006
EMBL· GenBank· DDBJ
EBV9029468.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHHID010000001
EMBL· GenBank· DDBJ
EBW5810643.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHYEX010000006
EMBL· GenBank· DDBJ
ECB6296911.1
EMBL· GenBank· DDBJ
Genomic DNA
AAIKEG010000007
EMBL· GenBank· DDBJ
ECF1312549.1
EMBL· GenBank· DDBJ
Genomic DNA
AAIKRN010000001
EMBL· GenBank· DDBJ
ECF2868499.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKIVL010000021
EMBL· GenBank· DDBJ
ECS2032798.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKJSR010000002
EMBL· GenBank· DDBJ
ECS4851943.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKJUD010000016
EMBL· GenBank· DDBJ
ECS4947087.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKMBR010000003
EMBL· GenBank· DDBJ
ECT2185157.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAGAR010000006
EMBL· GenBank· DDBJ
HAB2281253.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAGSQ010000010
EMBL· GenBank· DDBJ
HAB4397590.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAGZJ010000012
EMBL· GenBank· DDBJ
HAB5201211.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAHEO010000008
EMBL· GenBank· DDBJ
HAB5788078.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQZI010000003
EMBL· GenBank· DDBJ
HAE1521974.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARDU010000016
EMBL· GenBank· DDBJ
HAE2024007.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARRO010000004
EMBL· GenBank· DDBJ
HAE3645169.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASDA010000007
EMBL· GenBank· DDBJ
HAE5016385.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLP010000012
EMBL· GenBank· DDBJ
HAE6027127.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASSM010000008
EMBL· GenBank· DDBJ
HAE6816606.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASSE010000003
EMBL· GenBank· DDBJ
HAE6840211.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATPD010000012
EMBL· GenBank· DDBJ
HAE8988460.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATPM010000007
EMBL· GenBank· DDBJ
HAE9576640.1
EMBL· GenBank· DDBJ
Genomic DNA
VLRT01000009
EMBL· GenBank· DDBJ
TSH02476.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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