A0A3V2G0Q4 · A0A3V2G0Q4_SALET
- ProteinAspartate 1-decarboxylase
- GenepanD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids126 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Catalytic activity
- L-aspartate + H+ = beta-alanine + CO2
Cofactor
Note: Binds 1 pyruvoyl group covalently per subunit.
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 25 | Schiff-base intermediate with substrate; via pyruvic acid | |||
Binding site | 57 | substrate | |||
Active site | 58 | Proton donor | |||
Binding site | 73-75 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aspartate 1-decarboxylase activity | |
Biological Process | alanine biosynthetic process | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAspartate 1-decarboxylase
- EC number
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A3V2G0Q4
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_5035971818 | 1-24 | Aspartate 1-decarboxylase beta chain | ||
Modified residue | 25 | Pyruvic acid (Ser) | |||
Chain | PRO_5035971819 | 25-126 | Aspartate 1-decarboxylase alpha chain | ||
Post-translational modification
Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.
Keywords
- PTM
Interaction
Subunit
Heterooctamer of four alpha and four beta subunits.
Structure
Sequence
- Sequence statusComplete
- Length126
- Mass (Da)13,887
- Last updated2019-05-08 v1
- MD5 ChecksumF143CAD564DD47211293B3B2D157B134
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAHCWL010000005 EMBL· GenBank· DDBJ | EBU6914563.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHFAS010000073 EMBL· GenBank· DDBJ | EBV3764301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHGTQ010000047 EMBL· GenBank· DDBJ | EBV9203380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIGD010000005 EMBL· GenBank· DDBJ | EBW4104593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIXO010000006 EMBL· GenBank· DDBJ | EBW6732466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHKXZ010000024 EMBL· GenBank· DDBJ | EBX3357288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHOXC010000006 EMBL· GenBank· DDBJ | EBY7384885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHPAD010000006 EMBL· GenBank· DDBJ | EBY7626971.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHWIJ010000007 EMBL· GenBank· DDBJ | ECB0524043.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKLND010000047 EMBL· GenBank· DDBJ | ECT0412891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKPQX010000008 EMBL· GenBank· DDBJ | ECU3484204.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKTKA010000063 EMBL· GenBank· DDBJ | ECV4808638.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALIQJ010000057 EMBL· GenBank· DDBJ | EDA0177670.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALLSV010000013 EMBL· GenBank· DDBJ | EDA9403014.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALLTD010000007 EMBL· GenBank· DDBJ | EDA9437081.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMGJL010000008 EMBL· GenBank· DDBJ | EDH0980132.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMIHV010000043 EMBL· GenBank· DDBJ | EDH6431598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAMJL010000006 EMBL· GenBank· DDBJ | HAC6916783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARLP010000007 EMBL· GenBank· DDBJ | HAE2914405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARUC010000053 EMBL· GenBank· DDBJ | HAE3942377.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARUZ010000044 EMBL· GenBank· DDBJ | HAE4051119.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLG010000011 EMBL· GenBank· DDBJ | HAE6002113.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLQ010000088 EMBL· GenBank· DDBJ | HAE6034003.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASRW010000008 EMBL· GenBank· DDBJ | HAE6747771.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAATPN010000010 EMBL· GenBank· DDBJ | HAE9562920.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAUAM010000011 EMBL· GenBank· DDBJ | HAF0862166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RSGD01000008 EMBL· GenBank· DDBJ | MID45863.1 EMBL· GenBank· DDBJ | Genomic DNA |