A0A3V2FYX1 · A0A3V2FYX1_SALET

Function

function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Activity regulation

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

Pathway

Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site248-250NAD+ (UniProtKB | ChEBI)
Binding site298-300NAD+ (UniProtKB | ChEBI)
Binding site300K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site302K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site303IMP (UniProtKB | ChEBI)
Active site305Thioimidate intermediate
Binding site305K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site338-340IMP (UniProtKB | ChEBI)
Binding site361-362IMP (UniProtKB | ChEBI)
Binding site385-389IMP (UniProtKB | ChEBI)
Active site401Proton acceptor
Binding site415IMP (UniProtKB | ChEBI)
Binding site469K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners
Binding site470K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners
Binding site471K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners

GO annotations

AspectTerm
Molecular FunctionIMP dehydrogenase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP biosynthetic process
Biological ProcessGTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine-5'-monophosphate dehydrogenase
  • EC number
  • Short names
    IMP dehydrogenase
    ; IMPD
    ; IMPDH

Gene names

    • Name
      guaB
    • ORF names
      A4W49_19255
      , A4W57_20165
      , AIK92_10620
      , ASH82_17615
      , CB395_15130
      , CIL65_07295
      , D6J51_23155
      , D6K67_20240
      , DKU10_17480
      , DOJ23_17795
      , DP829_08745
      , DPJ44_19205
      , DPS10_17480
      , DQQ63_11330
      , DY868_09545
      , EUX26_18995
      , F9G64_23185
      , G0D76_21455
      , G3408_003234
      , G4B28_000420
      , G4B35_000394
      , G4I58_002459
      , G4I61_004499
      , G4L02_002569
      , G4Y23_001697
      , G9C15_000003
      , GCZ77_11845

Organism names

Accessions

  • Primary accession
    A0A3V2FYX1
  • Secondary accessions
    • A0A6C8XJA0

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain93-149CBS
Domain153-214CBS

Sequence similarities

Belongs to the IMPDH/GMPR family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    488
  • Mass (Da)
    51,948
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    A010555B6C67D0D5138C89FCF69FBAED
MLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLHEVKALTERNGFAGYPVVTEDNELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDNFHLLGMITVKDFQKAERKPNSCKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIQESHVHDVTITKESPNYRLGS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHCWL010000018
EMBL· GenBank· DDBJ
EBU6916476.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHFAS010000043
EMBL· GenBank· DDBJ
EBV3763375.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGTQ010000024
EMBL· GenBank· DDBJ
EBV9202405.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHIGD010000016
EMBL· GenBank· DDBJ
EBW4106222.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHIXO010000004
EMBL· GenBank· DDBJ
EBW6731915.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHKXZ010000016
EMBL· GenBank· DDBJ
EBX3356626.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHOXC010000030
EMBL· GenBank· DDBJ
EBY7387392.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHPAD010000018
EMBL· GenBank· DDBJ
EBY7628729.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHWIJ010000015
EMBL· GenBank· DDBJ
ECB0525233.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKLND010000012
EMBL· GenBank· DDBJ
ECT0410623.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKPQX010000003
EMBL· GenBank· DDBJ
ECU3482937.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKTKA010000011
EMBL· GenBank· DDBJ
ECV4805696.1
EMBL· GenBank· DDBJ
Genomic DNA
AALIQJ010000062
EMBL· GenBank· DDBJ
EDA0177736.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLSV010000019
EMBL· GenBank· DDBJ
EDA9403651.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLTD010000023
EMBL· GenBank· DDBJ
EDA9439098.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMGJL010000004
EMBL· GenBank· DDBJ
EDH0978879.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMIHV010000017
EMBL· GenBank· DDBJ
EDH6430152.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAMJL010000011
EMBL· GenBank· DDBJ
HAC6917711.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARLP010000006
EMBL· GenBank· DDBJ
HAE2914081.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARUC010000002
EMBL· GenBank· DDBJ
HAE3938501.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARUZ010000002
EMBL· GenBank· DDBJ
HAE4047332.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLG010000005
EMBL· GenBank· DDBJ
HAE6000855.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLQ010000106
EMBL· GenBank· DDBJ
HAE6034264.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASRW010000005
EMBL· GenBank· DDBJ
HAE6746838.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATPN010000003
EMBL· GenBank· DDBJ
HAE9560983.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAUAM010000001
EMBL· GenBank· DDBJ
HAF0860884.1
EMBL· GenBank· DDBJ
Genomic DNA
RSGD01000006
EMBL· GenBank· DDBJ
MID45405.1
EMBL· GenBank· DDBJ
Genomic DNA

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