A0A3V2FXT2 · A0A3V2FXT2_SALET

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site270Mn2+ 2 (UniProtKB | ChEBI)
Binding site275Mn2+ 2 (UniProtKB | ChEBI)
Binding site275Mn2+ 1 (UniProtKB | ChEBI)
Active site282
Binding site293Mn2+ 2 (UniProtKB | ChEBI)
Binding site352Mn2+ 1 (UniProtKB | ChEBI)
Binding site354Mn2+ 2 (UniProtKB | ChEBI)
Binding site354Mn2+ 1 (UniProtKB | ChEBI)
Active site356

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • ORF names
      A4W49_11140
      , A4W57_12850
      , AIK92_03665
      , ASH82_13845
      , CB395_07800
      , CIL65_15345
      , D6J51_12320
      , D6K67_13255
      , DKU10_10670
      , DOJ23_14955
      , DP829_13690
      , DPJ44_13815
      , DPS10_12940
      , DQQ63_07850
      , DY868_11855
      , EUX26_08570
      , F9G64_03315
      , G0D76_08580
      , G3408_002302
      , G4B28_004287
      , G4B35_001321
      , G4I58_002206
      , G4I61_004221
      , G4L02_002171
      , G4Y23_001299
      , G9C15_004226
      , GCZ77_07980

Organism names

Accessions

  • Primary accession
    A0A3V2FXT2
  • Secondary accessions
    • A0A6C8XE97

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain350-357Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    503
  • Mass (Da)
    54,890
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    340BDF3D5D1AF371A7F206B8AB170C41
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMRELGMNAYLAVGHGSQNESLMSVIEYKGNPSEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMSNHNPLAHELIGASEQAGDRAWRLPLGDEFQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLSQFLLNRAGFNGEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHCWL010000008
EMBL· GenBank· DDBJ
EBU6915163.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHFAS010000032
EMBL· GenBank· DDBJ
EBV3762824.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGTQ010000014
EMBL· GenBank· DDBJ
EBV9201679.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHIGD010000008
EMBL· GenBank· DDBJ
EBW4105180.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHIXO010000008
EMBL· GenBank· DDBJ
EBW6732866.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHKXZ010000009
EMBL· GenBank· DDBJ
EBX3355757.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHOXC010000008
EMBL· GenBank· DDBJ
EBY7385301.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHPAD010000008
EMBL· GenBank· DDBJ
EBY7627388.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHWIJ010000004
EMBL· GenBank· DDBJ
ECB0523217.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKLND010000006
EMBL· GenBank· DDBJ
ECT0409958.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKPQX010000004
EMBL· GenBank· DDBJ
ECU3483375.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKTKA010000026
EMBL· GenBank· DDBJ
ECV4807227.1
EMBL· GenBank· DDBJ
Genomic DNA
AALIQJ010000003
EMBL· GenBank· DDBJ
EDA0173871.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLSV010000007
EMBL· GenBank· DDBJ
EDA9402067.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLTD010000010
EMBL· GenBank· DDBJ
EDA9437683.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMGJL010000002
EMBL· GenBank· DDBJ
EDH0978129.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMIHV010000006
EMBL· GenBank· DDBJ
EDH6428720.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAMJL010000002
EMBL· GenBank· DDBJ
HAC6915252.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARLP010000003
EMBL· GenBank· DDBJ
HAE2913181.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARUC010000045
EMBL· GenBank· DDBJ
HAE3942222.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARUZ010000006
EMBL· GenBank· DDBJ
HAE4048221.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLG010000004
EMBL· GenBank· DDBJ
HAE6000611.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLQ010000089
EMBL· GenBank· DDBJ
HAE6034007.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASRW010000004
EMBL· GenBank· DDBJ
HAE6746452.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATPN010000002
EMBL· GenBank· DDBJ
HAE9560597.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAUAM010000068
EMBL· GenBank· DDBJ
HAF0864958.1
EMBL· GenBank· DDBJ
Genomic DNA
RSGD01000002
EMBL· GenBank· DDBJ
MID44072.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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