A0A3V2FX11 · A0A3V2FX11_SALET

Function

function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site10-13NADP+ (UniProtKB | ChEBI)
Binding site37-38NADP+ (UniProtKB | ChEBI)
Binding site74NADP+ (UniProtKB | ChEBI)
Binding site103phosphate (UniProtKB | ChEBI)
Active site136Acyl-thioester intermediate
Binding site163substrate
Binding site166-167NADP+ (UniProtKB | ChEBI)
Binding site242substrate
Binding site245phosphate (UniProtKB | ChEBI)
Binding site268substrate
Active site275Proton acceptor
Binding site351NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaspartate-semialdehyde dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionprotein dimerization activity
Biological Process'de novo' L-methionine biosynthetic process
Biological Processdiaminopimelate biosynthetic process
Biological Processisoleucine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate-semialdehyde dehydrogenase
  • EC number
  • Short names
    ASA dehydrogenase
    ; ASADH
  • Alternative names
    • Aspartate-beta-semialdehyde dehydrogenase

Gene names

    • Name
      asd
    • ORF names
      A4W49_05165
      , A4W57_09090
      , AIK92_06655
      , ASH82_11540
      , CB395_05065
      , CIL65_01465
      , D6J51_09490
      , D6K67_10430
      , DKU10_05655
      , DOJ23_03715
      , DP829_10945
      , DPJ44_08580
      , DPS10_12305
      , DQQ63_10340
      , DY868_13515
      , EUX26_12055
      , F9G64_02560
      , G0D76_12030
      , G3408_002902
      , G4B28_001014
      , G4B35_001823
      , G4I58_003102
      , G4I61_000604
      , G4L02_003139
      , G4Y23_002260
      , G9C15_000549
      , GCZ77_10705

Organism names

Accessions

  • Primary accession
    A0A3V2FX11
  • Secondary accessions
    • A0A6C8XH71

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-123Semialdehyde dehydrogenase NAD-binding

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    368
  • Mass (Da)
    40,136
  • Last updated
    2019-05-08 v1
  • Checksum
    08BFB3E98029A677
MKNVGFIGWRGMVGSVLMQRMVEERDFDAIRPVFFSTSQFGQAAPTFGDTSTGTLQDAFDLDALKALDIIVTCQGGDYTNEIYPKLRESGWQGYWIDAASTLRMKDDAIIILDPVNQDVITDGLNNGVKTFVGGNCTVSLMLMSLGGLFAHNLVDWVSVATYQAASGGGARHMRELLTQMGQLYGHVADELATPSSAILDIERKVTALTRSGELPVDNFGVPLAGSLIPWIDKQLDNGQSREEWKGQAETNKILNTASVIPVDGLCVRVGALRCHSQAFTIKLKKEVSIPTVEELLAAHNPWAKVVPNDRDITMRELTPAAVTGTLTTPVGRLRKLNMGPEFLSAFTVGDQLLWGAAEPLRRMLRQLA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHCWL010000003
EMBL· GenBank· DDBJ
EBU6914203.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHFAS010000005
EMBL· GenBank· DDBJ
EBV3760651.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHGTQ010000011
EMBL· GenBank· DDBJ
EBV9201240.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHIGD010000003
EMBL· GenBank· DDBJ
EBW4104168.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHIXO010000005
EMBL· GenBank· DDBJ
EBW6732339.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHKXZ010000008
EMBL· GenBank· DDBJ
EBX3355637.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHOXC010000005
EMBL· GenBank· DDBJ
EBY7384758.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHPAD010000005
EMBL· GenBank· DDBJ
EBY7626844.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHWIJ010000006
EMBL· GenBank· DDBJ
ECB0523887.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKLND010000010
EMBL· GenBank· DDBJ
ECT0410436.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKPQX010000005
EMBL· GenBank· DDBJ
ECU3483690.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKTKA010000002
EMBL· GenBank· DDBJ
ECV4804567.1
EMBL· GenBank· DDBJ
Genomic DNA
AALIQJ010000002
EMBL· GenBank· DDBJ
EDA0173724.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLSV010000002
EMBL· GenBank· DDBJ
EDA9400921.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLTD010000006
EMBL· GenBank· DDBJ
EDA9436959.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMGJL010000003
EMBL· GenBank· DDBJ
EDH0978654.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMIHV010000003
EMBL· GenBank· DDBJ
EDH6428189.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAMJL010000003
EMBL· GenBank· DDBJ
HAC6915916.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARLP010000004
EMBL· GenBank· DDBJ
HAE2913762.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARUC010000004
EMBL· GenBank· DDBJ
HAE3939074.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARUZ010000009
EMBL· GenBank· DDBJ
HAE4048705.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLG010000007
EMBL· GenBank· DDBJ
HAE6001472.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLQ010000006
EMBL· GenBank· DDBJ
HAE6030505.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASRW010000006
EMBL· GenBank· DDBJ
HAE6747388.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATPN010000004
EMBL· GenBank· DDBJ
HAE9561526.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAUAM010000004
EMBL· GenBank· DDBJ
HAF0861404.1
EMBL· GenBank· DDBJ
Genomic DNA
RSGD01000003
EMBL· GenBank· DDBJ
MID44645.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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