A0A3V2FX11 · A0A3V2FX11_SALET
- ProteinAspartate-semialdehyde dehydrogenase
- Geneasd
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids368 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Catalytic activity
- L-aspartate 4-semialdehyde + phosphate + NADP+ = 4-phospho-L-aspartate + NADPH + H+
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10-13 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: RGMV | ||||||
Binding site | 37-38 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: TS | ||||||
Binding site | 74 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 103 | phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 136 | Acyl-thioester intermediate | ||||
Sequence: C | ||||||
Binding site | 163 | substrate | ||||
Sequence: Q | ||||||
Binding site | 166-167 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: SG | ||||||
Binding site | 242 | substrate | ||||
Sequence: E | ||||||
Binding site | 245 | phosphate (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 268 | substrate | ||||
Sequence: R | ||||||
Active site | 275 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 351 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aspartate-semialdehyde dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | NADP binding | |
Molecular Function | protein dimerization activity | |
Biological Process | 'de novo' L-methionine biosynthetic process | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | isoleucine biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAspartate-semialdehyde dehydrogenase
- EC number
- Short namesASA dehydrogenase ; ASADH
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A3V2FX11
- Secondary accessions
Proteomes
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-123 | Semialdehyde dehydrogenase NAD-binding | ||||
Sequence: NVGFIGWRGMVGSVLMQRMVEERDFDAIRPVFFSTSQFGQAAPTFGDTSTGTLQDAFDLDALKALDIIVTCQGGDYTNEIYPKLRESGWQGYWIDAASTLRMKDDAIIILDPVNQDVITDG |
Sequence similarities
Belongs to the aspartate-semialdehyde dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)40,136
- Last updated2019-05-08 v1
- Checksum08BFB3E98029A677
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAHCWL010000003 EMBL· GenBank· DDBJ | EBU6914203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHFAS010000005 EMBL· GenBank· DDBJ | EBV3760651.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHGTQ010000011 EMBL· GenBank· DDBJ | EBV9201240.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIGD010000003 EMBL· GenBank· DDBJ | EBW4104168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIXO010000005 EMBL· GenBank· DDBJ | EBW6732339.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHKXZ010000008 EMBL· GenBank· DDBJ | EBX3355637.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHOXC010000005 EMBL· GenBank· DDBJ | EBY7384758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHPAD010000005 EMBL· GenBank· DDBJ | EBY7626844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHWIJ010000006 EMBL· GenBank· DDBJ | ECB0523887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKLND010000010 EMBL· GenBank· DDBJ | ECT0410436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKPQX010000005 EMBL· GenBank· DDBJ | ECU3483690.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKTKA010000002 EMBL· GenBank· DDBJ | ECV4804567.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALIQJ010000002 EMBL· GenBank· DDBJ | EDA0173724.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALLSV010000002 EMBL· GenBank· DDBJ | EDA9400921.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALLTD010000006 EMBL· GenBank· DDBJ | EDA9436959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMGJL010000003 EMBL· GenBank· DDBJ | EDH0978654.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMIHV010000003 EMBL· GenBank· DDBJ | EDH6428189.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAMJL010000003 EMBL· GenBank· DDBJ | HAC6915916.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARLP010000004 EMBL· GenBank· DDBJ | HAE2913762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARUC010000004 EMBL· GenBank· DDBJ | HAE3939074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARUZ010000009 EMBL· GenBank· DDBJ | HAE4048705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLG010000007 EMBL· GenBank· DDBJ | HAE6001472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLQ010000006 EMBL· GenBank· DDBJ | HAE6030505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASRW010000006 EMBL· GenBank· DDBJ | HAE6747388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAATPN010000004 EMBL· GenBank· DDBJ | HAE9561526.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAUAM010000004 EMBL· GenBank· DDBJ | HAF0861404.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RSGD01000003 EMBL· GenBank· DDBJ | MID44645.1 EMBL· GenBank· DDBJ | Genomic DNA |