A0A3V2FVK8 · A0A3V2FVK8_SALET

Function

function

Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
    EC:3.1.26.12 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per homotetramer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site303Mg2+ (UniProtKB | ChEBI); catalytic
Binding site346Mg2+ (UniProtKB | ChEBI); catalytic
Binding site404Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site407Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic side of plasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionribonuclease E activity
Molecular FunctionRNA endonuclease activity
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Molecular Functionzinc ion binding
Biological ProcessmRNA catabolic process
Biological ProcessrRNA processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease E
  • EC number
  • Short names
    RNase E

Gene names

    • Name
      rne
    • ORF names
      A4W49_00120
      , A4W57_05560
      , AIK92_00750
      , CB395_15815
      , D6J51_03640
      , D6K67_01830
      , DOJ23_09830
      , DP829_01830
      , DPJ44_01825
      , DPS10_07025
      , DQQ63_00240
      , DY868_01055
      , EUX26_04290
      , F9G64_00215
      , G3408_000344
      , G4B28_002556
      , G4B35_001255
      , G4I58_001155
      , G4I61_000868
      , G4L02_000466
      , G4Y23_000194
      , G9C15_002236
      , GCZ77_01705

Organism names

Accessions

  • Primary accession
    A0A3V2FVK8
  • Secondary accessions
    • A0A6C8XDY9

Proteomes

Subcellular Location

Cytoplasm
Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain39-119S1 motif
Region404-407Required for zinc-mediated homotetramerization and catalytic activity
Region585-730Disordered
Compositional bias589-717Basic and acidic residues
Region747-766Disordered
Region775-820Disordered
Compositional bias780-795Basic and acidic residues
Region1010-1067Disordered

Sequence similarities

Belongs to the RNase E/G family. RNase E subfamily.
Belongs to the RNase E/G family. RNase G subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,067
  • Mass (Da)
    119,392
  • Last updated
    2019-05-08 v1
  • Checksum
    9914E5FA3E98339B
MKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYKGKITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFPANYSAHGRPNIKDVLREGQEVIVQIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIEGDDRTELKEALASLELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIQKAAESRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPKVMEMARQHIAALGRPDFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIDINSARATRGGDIEETAFNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVENRLREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGTVRDNESLSLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRTAVNAIETRQDGVRCVIVPNDQMETPHYSVLRVRKGEETPTLSYMLPKLHEEAMALPSEEEYAERKRPEQPALATFAMPDVPPAPTPVEPAVSVATAKKDNVAAAQPAQPGLFSRFLNALKQLFSGEETKAVETAAPKAEEKAERQQDRRKPRQNNRRDRNERRDTRDNRAGRDGGESRDDNRRNRRQAQQQNAEARDTRQQETAEKVKTGDEQQQTPRRERSRRRNDDKRQAQQEVKALNREEQPVQETEQEERVQQVQPRRKQRQLNQKVRFTNSAVVETVDTPVVVDEPRPVENVEQPVPAPRTELAKVDLPVVADIAPEQDDSVEPRDNTGMPRRSRRSPRHLRVSGQRRRRYRDERYPTQSPMPLTVACASPEMASGKVWIRYPIVRPQETQVVEEQREADLALPQPVVAEPQVIAATVALEPQASVQAVENVAVEPQTVAEPQAPEVVKVETTHPEVIAAPVDEQPQLIAESDTPEAQEVIADAEPVAETADASITVAENVADVVVVEPEEETKAEAAVVEHTAEETVIAPAQVVEKPQDVVCVDDHNHASAPMTRAPAPEYVPETPHHSDWQRPSFHFEGKGAAGGHSATRHASAPATRPQPVE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias589-717Basic and acidic residues
Compositional bias780-795Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHFAS010000017
EMBL· GenBank· DDBJ
EBV3761841.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHIGD010000001
EMBL· GenBank· DDBJ
EBW4102877.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHIXO010000001
EMBL· GenBank· DDBJ
EBW6730602.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHKXZ010000004
EMBL· GenBank· DDBJ
EBX3354614.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHOXC010000002
EMBL· GenBank· DDBJ
EBY7383641.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHPAD010000001
EMBL· GenBank· DDBJ
EBY7625204.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHWIJ010000002
EMBL· GenBank· DDBJ
ECB0522393.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKLND010000001
EMBL· GenBank· DDBJ
ECT0408508.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKPQX010000001
EMBL· GenBank· DDBJ
ECU3481314.1
EMBL· GenBank· DDBJ
Genomic DNA
AALIQJ010000001
EMBL· GenBank· DDBJ
EDA0173271.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLSV010000001
EMBL· GenBank· DDBJ
EDA9399945.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLTD010000004
EMBL· GenBank· DDBJ
EDA9436276.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMGJL010000001
EMBL· GenBank· DDBJ
EDH0976922.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMIHV010000018
EMBL· GenBank· DDBJ
EDH6430287.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARLP010000001
EMBL· GenBank· DDBJ
HAE2911297.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARUC010000016
EMBL· GenBank· DDBJ
HAE3940566.1
EMBL· GenBank· DDBJ
Genomic DNA
DAARUZ010000005
EMBL· GenBank· DDBJ
HAE4048157.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLG010000002
EMBL· GenBank· DDBJ
HAE5999593.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASLQ010000009
EMBL· GenBank· DDBJ
HAE6030761.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASRW010000001
EMBL· GenBank· DDBJ
HAE6744815.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATPN010000001
EMBL· GenBank· DDBJ
HAE9559539.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAUAM010000021
EMBL· GenBank· DDBJ
HAF0863045.1
EMBL· GenBank· DDBJ
Genomic DNA
RSGD01000001
EMBL· GenBank· DDBJ
MID43516.1
EMBL· GenBank· DDBJ
Genomic DNA

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