A0A3V2FU22 · A0A3V2FU22_SALET
- ProteinATP-dependent DNA helicase DinG
- GenedinG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids716 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
DNA-dependent ATPase and 5'-3' DNA helicase. Unwinds D-loops, R-loops, forked DNA and G-quadruplex DNA.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 120 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 194 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 199 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 205 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | 5'-3' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA/RNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA repair | |
Biological Process | SOS response |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase DinG
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A3V2FU22
- Secondary accessions
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 17-294 | Helicase ATP-binding | |||
Sequence similarities
Family and domain databases
Sequence
- Sequence statusComplete
- Length716
- Mass (Da)81,205
- Last updated2019-05-08 v1
- MD5 Checksum2691A6C0BD965672F829CE87FC62B33F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAHCWL010000011 EMBL· GenBank· DDBJ | EBU6915750.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHFAS010000070 EMBL· GenBank· DDBJ | EBV3764269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIGD010000001 EMBL· GenBank· DDBJ | EBW4102585.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIXO010000001 EMBL· GenBank· DDBJ | EBW6730309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHKXZ010000002 EMBL· GenBank· DDBJ | EBX3353982.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHOXC010000009 EMBL· GenBank· DDBJ | EBY7385543.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHPAD010000001 EMBL· GenBank· DDBJ | EBY7624911.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHWIJ010000010 EMBL· GenBank· DDBJ | ECB0524676.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKLND010000011 EMBL· GenBank· DDBJ | ECT0410563.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKPQX010000012 EMBL· GenBank· DDBJ | ECU3484834.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALIQJ010000018 EMBL· GenBank· DDBJ | EDA0175675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALLSV010000010 EMBL· GenBank· DDBJ | EDA9402652.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALLTD010000002 EMBL· GenBank· DDBJ | EDA9435675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMGJL010000001 EMBL· GenBank· DDBJ | EDH0976645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMIHV010000020 EMBL· GenBank· DDBJ | EDH6430485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARLP010000001 EMBL· GenBank· DDBJ | HAE2911019.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARUC010000010 EMBL· GenBank· DDBJ | HAE3939927.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARUZ010000019 EMBL· GenBank· DDBJ | HAE4049776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLG010000002 EMBL· GenBank· DDBJ | HAE5999314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLQ010000010 EMBL· GenBank· DDBJ | HAE6030847.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASRW010000001 EMBL· GenBank· DDBJ | HAE6744482.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAATPN010000008 EMBL· GenBank· DDBJ | HAE9562649.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAUAM010000006 EMBL· GenBank· DDBJ | HAF0861665.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RSGD01000013 EMBL· GenBank· DDBJ | MID46678.1 EMBL· GenBank· DDBJ | Genomic DNA |