A0A3V2FR94 · A0A3V2FR94_SALET
- Protein2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- GeneispF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids159 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
Catalytic activity
- 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP
Cofactor
Note: Binds 1 divalent metal cation per subunit.
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 8 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 8-10 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 10 | a divalent metal cation (UniProtKB | ChEBI) | |||
Site | 34 | Transition state stabilizer | |||
Binding site | 34-35 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 42 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 56-58 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 61-65 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 100-106 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 132-135 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Site | 133 | Transition state stabilizer | |||
Binding site | 139 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 142 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity | |
Molecular Function | metal ion binding | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | terpenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- EC number
- Short namesMECDP-synthase ; MECPP-synthase ; MECPS
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A3V2FR94
- Secondary accessions
Proteomes
Interaction
Subunit
Homotrimer.
Structure
Sequence
- Sequence statusComplete
- Length159
- Mass (Da)16,900
- Last updated2019-05-08 v1
- MD5 Checksum0607882418E57385FA287DD7A4C8B8CC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAHCWL010000017 EMBL· GenBank· DDBJ | EBU6916464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHFAS010000012 EMBL· GenBank· DDBJ | EBV3761430.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHGTQ010000008 EMBL· GenBank· DDBJ | EBV9200893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIGD010000012 EMBL· GenBank· DDBJ | EBW4105826.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIXO010000010 EMBL· GenBank· DDBJ | EBW6733273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHKXZ010000005 EMBL· GenBank· DDBJ | EBX3354998.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHOXC010000007 EMBL· GenBank· DDBJ | EBY7385131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHPAD010000007 EMBL· GenBank· DDBJ | EBY7627217.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHWIJ010000008 EMBL· GenBank· DDBJ | ECB0524284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKLND010000019 EMBL· GenBank· DDBJ | ECT0411443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKPQX010000002 EMBL· GenBank· DDBJ | ECU3482587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALIQJ010000008 EMBL· GenBank· DDBJ | EDA0174683.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALLSV010000005 EMBL· GenBank· DDBJ | EDA9401694.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALLTD010000011 EMBL· GenBank· DDBJ | EDA9437910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMGJL010000007 EMBL· GenBank· DDBJ | EDH0979961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMIHV010000007 EMBL· GenBank· DDBJ | EDH6428895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAMJL010000004 EMBL· GenBank· DDBJ | HAC6916176.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARLP010000002 EMBL· GenBank· DDBJ | HAE2912592.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARUC010000007 EMBL· GenBank· DDBJ | HAE3939449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARUZ010000038 EMBL· GenBank· DDBJ | HAE4050949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLG010000003 EMBL· GenBank· DDBJ | HAE6000023.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLQ010000041 EMBL· GenBank· DDBJ | HAE6032711.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASRW010000002 EMBL· GenBank· DDBJ | HAE6745245.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAATPN010000007 EMBL· GenBank· DDBJ | HAE9562371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAUAM010000024 EMBL· GenBank· DDBJ | HAF0863316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RSGD01000009 EMBL· GenBank· DDBJ | MID46162.1 EMBL· GenBank· DDBJ | Genomic DNA |