A0A3V1N9X2 · A0A3V1N9X2_SALET

  • Protein
    4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
  • Gene
    hpaI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Pathway

Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7.

Features

Showing features for active site, site, binding site.

TypeIDPosition(s)Description
Active site45Proton acceptor
Site70Transition state stabilizer
Site84Increases basicity of active site His
Binding site147substrate
Binding site149a divalent metal cation (UniProtKB | ChEBI)
Binding site174substrate
Binding site175a divalent metal cation (UniProtKB | ChEBI)
Binding site175substrate

GO annotations

AspectTerm
Molecular Function2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity
Molecular Functionaldehyde-lyase activity
Molecular Functionmetal ion binding
Biological Processphenylacetate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
  • EC number
  • Alternative names
    • 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase
      (HHED aldolase
      )
    • 4-hydroxy-2-ketoheptane-1,7-dioate aldolase
      (HKHD aldolase
      )

Gene names

    • Name
      hpaI
    • Synonyms
      hpcH
    • ORF names
      E2856_06935
      , F2J49_05770
      , G1H57_02165
      , RU46_11690

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 702933
    • 800600
    • Salmonella enterica subsp. enterica
    • CFSAN025702
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    A0A3V1N9X2

Proteomes

Interaction

Subunit

Homohexamer; trimer of dimers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-240HpcH/HpaI aldolase/citrate lyase

Sequence similarities

Belongs to the HpcH/HpaI aldolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    27,758
  • Last updated
    2019-12-11 v1
  • Checksum
    52CC25BC0244BBB9
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHLANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKNLSGASGVY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAIYPR010000006
EMBL· GenBank· DDBJ
ECJ5164795.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKIYB010000006
EMBL· GenBank· DDBJ
ECS2351704.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKTCM010000003
EMBL· GenBank· DDBJ
ECV1971136.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAODK010000001
EMBL· GenBank· DDBJ
HAD2565895.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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