A0A3T4RMW8 · A0A3T4RMW8_SALET

  • Protein
    Signal recognition particle receptor FtsY
  • Gene
    ftsY
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.

Catalytic activity

Features

Showing features for binding site.

149150100150200250300350400450
TypeIDPosition(s)Description
Binding site294-301GTP (UniProtKB | ChEBI)
Binding site376-380GTP (UniProtKB | ChEBI)
Binding site440-443GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle receptor FtsY
  • EC number
  • Short names
    SRP receptor

Gene names

    • Name
      ftsY
    • ORF names
      DAX60_001355
      , XB40_001410
      , Z599_01310

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • CFSAN058588
    • CFSAN001999
    • MDH-2013-00175
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    A0A3T4RMW8

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-58Disordered
Compositional bias19-33Basic and acidic residues
Region70-89Disordered
Domain461-474SRP54-type proteins GTP-binding

Domain

Contains an acidic N-terminal A domain, a central N domain and a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains at least two lipid-binding sites. The first site contains the first 14 amino acids (helix 1) and the second binding site is an amphipathic alpha-helix located at the interface between the A- and the N-domain (helix 2).

Sequence similarities

Belongs to the GTP-binding SRP family. FtsY subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    491
  • Mass (Da)
    53,777
  • Last updated
    2019-05-08 v1
  • Checksum
    1D43F7DB77B2D8E3
MAKQKKRGFFSWLGFGDKEQKQEQTEEQQIVEEQRPVEPPVETAADIDAQTPAHSKAETEAFAEEVVDVTEKVQESEKPQPVEPEPATAVETAAPQIAVEREELLLPEEVKDEAISPEEWQAEAETVEVIAAVEEEGENAAKFTDEELEAQALAAQAAEEAVMVVPPAEEDAPVEAIVQEQEKPTKEGFFARLKRSLLKTKENLGSGFISLFRGKKIDDDLFEELEEQLLIADVGVETTRKIIANLTEGASRKQLKDAEALYGLLKDEMGEILAKVDEPLNIEGKTPFVILMVGVNGVGKTTTIGKLARQFEQQGKSVMLAAGDTFRAAAVEQLQVWGQRNNIPVIAQHTGADSASVIFDAIQAAKARNVDVLIADTAGRLQNKSHLMEELKKIVRVMKKLDEEAPHEVMLTIDASTGQNAVSQAKLFHEAVGLTGITLTKLDGTAKGGVIFSVADQFGIPIRYIGVGERIEDLRPFKADDFIEALFARED

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias19-33Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGLQK010000001
EMBL· GenBank· DDBJ
EBP4056412.1
EMBL· GenBank· DDBJ
Genomic DNA
CP074675
EMBL· GenBank· DDBJ
QWI80807.1
EMBL· GenBank· DDBJ
Genomic DNA
CP077702
EMBL· GenBank· DDBJ
QXR63995.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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