A0A3T3G9L7 · A0A3T3G9L7_SALET
- ProteinNADH-quinone oxidoreductase
- GenenuoG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids910 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a quinone + NADH + 5 H+(in) = a quinol + NAD+ + 4 H+(out)
CHEBI:132124 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= CHEBI:24646 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [2Fe-2S] cluster per subunit.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | oxidoreductase complex | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | molybdopterin cofactor binding | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Molecular Function | quinone binding | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A3T3G9L7
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-85 | 2Fe-2S ferredoxin-type | |||
Domain | 85-124 | 4Fe-4S His(Cys)3-ligated-type | |||
Domain | 223-279 | 4Fe-4S Mo/W bis-MGD-type | |||
Sequence similarities
Belongs to the complex I 75 kDa subunit family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length910
- Mass (Da)100,272
- Last updated2019-05-08 v1
- MD5 Checksum1287EA0E814D2FDDEF73D095443BF73B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAHCWL010000010 EMBL· GenBank· DDBJ | EBU6915564.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHFAS010000009 EMBL· GenBank· DDBJ | EBV3761018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIGD010000007 EMBL· GenBank· DDBJ | EBW4105042.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHIXO010000004 EMBL· GenBank· DDBJ | EBW6732106.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHKXZ010000010 EMBL· GenBank· DDBJ | EBX3355975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHOXC010000010 EMBL· GenBank· DDBJ | EBY7385692.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHPAD010000010 EMBL· GenBank· DDBJ | EBY7627789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKLND010000002 EMBL· GenBank· DDBJ | ECT0409154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKPQX010000003 EMBL· GenBank· DDBJ | ECU3483128.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKTKA010000009 EMBL· GenBank· DDBJ | ECV4805508.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAMJL010000009 EMBL· GenBank· DDBJ | HAC6917452.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RSGD01000006 EMBL· GenBank· DDBJ | MID45596.1 EMBL· GenBank· DDBJ | Genomic DNA |