A0A3T2YM36 · A0A3T2YM36_SALET

Function

function

Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site119Important for catalytic activity
Site139Important for catalytic activity
Binding site296substrate
Binding site324NAD+ (UniProtKB | ChEBI)
Binding site343NAD+ (UniProtKB | ChEBI)
Binding site400-402NAD+ (UniProtKB | ChEBI)
Binding site407NAD+ (UniProtKB | ChEBI)
Binding site429NAD+ (UniProtKB | ChEBI)
Active site450For 3-hydroxyacyl-CoA dehydrogenase activity
Binding site453NAD+ (UniProtKB | ChEBI)
Binding site500substrate
Binding site660substrate

GO annotations

AspectTerm
Cellular Componentfatty acid beta-oxidation multienzyme complex
Molecular Function3-hydroxyacyl-CoA dehydrogenase activity
Molecular Function3-hydroxybutyryl-CoA epimerase activity
Molecular Functiondelta(3)-delta(2)-enoyl-CoA isomerase activity
Molecular Functionenoyl-CoA hydratase activity
Molecular FunctionNAD+ binding
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fatty acid oxidation complex subunit alpha

Including 2 domains:

  • Recommended name
    Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase
  • EC number
  • Recommended name
    3-hydroxyacyl-CoA dehydrogenase
  • EC number

Gene names

    • Name
      fadB
    • ORF names
      A4I59_12960
      , ATT75_12675
      , B9668_20860
      , BZZ78_21610
      , CC707_17340
      , DNP18_19560
      , DOI44_21975
      , DVF77_18080
      , EVY66_19750
      , G9X39_004428

Organism names

  • Taxonomic identifier
  • Strains
    • 116565
    • 245122
    • 333397
    • 449454
    • 13-2237
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    A0A3T2YM36

Proteomes

Interaction

Subunit

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-189Enoyl-CoA hydratase/isomerase
Region311-7293-hydroxyacyl-CoA dehydrogenase
Domain316-4943-hydroxyacyl-CoA dehydrogenase NAD binding
Domain496-5923-hydroxyacyl-CoA dehydrogenase C-terminal
Domain627-6913-hydroxyacyl-CoA dehydrogenase C-terminal
Region708-729Disordered

Sequence similarities

In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    729
  • Mass (Da)
    79,644
  • Last updated
    2019-05-08 v1
  • Checksum
    5D273293BBD8D7E8
MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGQALEVLEKQHDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTLAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDIGAEQALKIGLVDGVVKQEKLIDGAIAVLRQAITGDLDWRAKRQPKLEPLKLSKIEAAMSFTIAKGMVAQTAGKHYPAPMTAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDIETPKQAAVLGAGIMGGGIAYQSAWKGVPVIMKDINDKSLNLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPETVLASNTSTIPIGELASALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKEYRDAIDALFDASRFGQKNGLGFWRYKEDNKGKPKKEEDAAVDDLLASVSQPKRDFSDDEIIARMMIPMINEVVRCLEEGIIASPAEADMALVYGLGFPPFHGGAFRWLDTQGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGSLKTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGTPA010000031
EMBL· GenBank· DDBJ
EBR8435640.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHNRG010000027
EMBL· GenBank· DDBJ
EBY2812893.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHXAU010000018
EMBL· GenBank· DDBJ
ECB2721752.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKRFC010000015
EMBL· GenBank· DDBJ
ECU8397741.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKZQX010000016
EMBL· GenBank· DDBJ
ECX6033624.1
EMBL· GenBank· DDBJ
Genomic DNA
AALLIO010000021
EMBL· GenBank· DDBJ
EDA8187681.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMFVA010000012
EMBL· GenBank· DDBJ
EDG9354802.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMJPF010000024
EMBL· GenBank· DDBJ
EDI0272864.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAWCK010000066
EMBL· GenBank· DDBJ
HAF7259603.1
EMBL· GenBank· DDBJ
Genomic DNA
QLHR01000014
EMBL· GenBank· DDBJ
TRS90585.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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