A0A3S9MZ36 · A0A3S9MZ36_9FLAO

  • Protein
    Diaminopimelate decarboxylase
  • Gene
    lysA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site218pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site298substrate
Binding site302substrate
Active site328Proton donor
Binding site329substrate
Binding site356pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site356substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      EJ995_09295

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MJ115
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Nonlabens

Accessions

  • Primary accession
    A0A3S9MZ36

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue49N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-266Orn/DAP/Arg decarboxylase 2 N-terminal
Domain267-354Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    410
  • Mass (Da)
    45,416
  • Last updated
    2019-05-08 v1
  • Checksum
    A6C151238387C64C
MNAQDLLNIAQEHGSPVYVYDAATMVSQYERLTSAFAKVENLRIHYAVKALSNISILKLFKQLGARLDTVSLQEVKLGLAAGVDPAKIIYTPNGVSLEEIERVAEMGVQINIDNLSILEQFGAKHPTVPVCVRINPHVMAGGNANISVGHIDSKFGISIHQIPLLLRIVENTGMKVNGVHMHTGSDILDIGVFLYATEILFETAAKFKDLEFIDFGSGFKVPYKEGDVSTDIEELGDQLSDRFNEFCKSYGKDIALAFEPGKFLVSQSGHFLAQVNVIKQTTSTVFAHIDTGFNHLIRPMMYGSYHGITNISNIDGKNRFYSVVGYICETDTFANNRQISEIAEGDILSFSNAGAYCFSMASNYNSRYRPAEVLWHNGKAHLIRERETFDDILNKQVDVEIEVGGEFVEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP034549
EMBL· GenBank· DDBJ
AZQ44427.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp