A0A3S9MUC2 · A0A3S9MUC2_9FLAO
- ProteinNa(+)-translocating NADH-quinone reductase subunit F
- GenenqrF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids433 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
Catalytic activity
- a ubiquinone + H+ + n Na+(in) + NADH = a ubiquinol + n Na+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + CHEBI:15378 + n Na+ (in)CHEBI:29101+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + n Na+ (out)CHEBI:29101+ CHEBI:57540
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [2Fe-2S] cluster.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | electron transfer activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
Biological Process | sodium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNa(+)-translocating NADH-quinone reductase subunit F
- EC number
- Short namesNa(+)-NQR subunit F ; Na(+)-translocating NQR subunit F
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Nonlabens
Accessions
- Primary accessionA0A3S9MUC2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-27 | Helical | ||||
Sequence: ITILASAAIFLVLILLLVTLLL |
Keywords
- Cellular component
Interaction
Subunit
Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 37-129 | 2Fe-2S ferredoxin-type | ||||
Sequence: GPVTINVNGEKDITTGSGGTLLGTLGDNKLFLPSACGGGGTCVQCKCVVTDGGGSILPTEVPHFTRKEIAAGWRLGCQVKVKQDMKIEIPEEV | ||||||
Domain | 132-284 | FAD-binding FR-type | ||||
Sequence: IKKWEAEVVRNYNVASFIKEFVVRLPEDMDYEAGGYIQIEIPKCEVKYQDMDITAHPEEHDTADKFQAEWDKFNLWPLVMKNPETVERAYSMASFPAEGREIMLNVRIATPPWDRAKNNWMDVNPGIASSYIFNQKPGDKVIISGPYGEFFIN |
Sequence similarities
Belongs to the NqrF family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length433
- Mass (Da)48,609
- Last updated2019-05-08 v1
- ChecksumDF2EFBA77BEDC123
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP034549 EMBL· GenBank· DDBJ | AZQ42779.1 EMBL· GenBank· DDBJ | Genomic DNA |