A0A3S7U953 · A0A3S7U953_9BIVA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids182 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Palaeoheterodonta > Unionida > Unionoidea > Unionidae > Unioninae > Unio
Accessions
- Primary accessionA0A3S7U953
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 22-48 | Helical | |||
Transmembrane | 69-87 | Helical | |||
Transmembrane | 107-131 | Helical | |||
Transmembrane | 152-179 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length182
- Mass (Da)19,191
- Last updated2019-05-08 v1
- MD5 Checksum8FF4081B2D25283E9A4063CB19838E86
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 182 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MG967427 EMBL· GenBank· DDBJ | AYF61283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967428 EMBL· GenBank· DDBJ | AYF61284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967429 EMBL· GenBank· DDBJ | AYF61285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967430 EMBL· GenBank· DDBJ | AYF61286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967431 EMBL· GenBank· DDBJ | AYF61287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967432 EMBL· GenBank· DDBJ | AYF61288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967433 EMBL· GenBank· DDBJ | AYF61289.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967434 EMBL· GenBank· DDBJ | AYF61290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967435 EMBL· GenBank· DDBJ | AYF61291.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967436 EMBL· GenBank· DDBJ | AYF61292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967437 EMBL· GenBank· DDBJ | AYF61293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967438 EMBL· GenBank· DDBJ | AYF61294.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967439 EMBL· GenBank· DDBJ | AYF61295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967440 EMBL· GenBank· DDBJ | AYF61296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967441 EMBL· GenBank· DDBJ | AYF61297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967442 EMBL· GenBank· DDBJ | AYF61298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967444 EMBL· GenBank· DDBJ | AYF61300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967445 EMBL· GenBank· DDBJ | AYF61301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG967446 EMBL· GenBank· DDBJ | AYF61302.1 EMBL· GenBank· DDBJ | Genomic DNA |