A0A3S4M488 · A0A3S4M488_CHRGE

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

138250100150200250300350
TypeIDPosition(s)Description
Binding site9Mg2+ (UniProtKB | ChEBI)
Site14Substrate discrimination
Binding site102Mg2+ (UniProtKB | ChEBI)
Active site103

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA-templated DNA replication
Biological Processerror-prone translesion synthesis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB_5
    • Synonyms
      dinB
    • ORF names
      NCTC11432_04653

Organism names

Accessions

  • Primary accession
    A0A3S4M488

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-183UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    382
  • Mass (Da)
    42,940
  • Last updated
    2019-04-10 v1
  • Checksum
    F7F26B65F3BCF561
MERSIVHLDLDTFFVSCERLVNSGLNGIPLIIGGGDRGVVSSCSYEARTFGVRSAMPMKMALRLCPQAKVVKGDMELYSRMSHTVTEVIEESAPVMEKASIDEFYLDLTGMDKFFGAYKWTNELGAKIEKETGLPISYALSTNKTVSKIGTGESKPHGHREIPSLGVQSFLNPLSIKKMPMVGNATFQLFSRVGIRTIGTLSEMPVEILQQMIGKNGTDLWKKANGIDETPVIPYSERKSISKERTFSSDTMDTYEVKGLISGMAEQLAHQLRQEKWLTSTVVIKIRYSNFDTESKQCRVSYTSSDHTLARVALELFDKIYTRRMRLRLVGLRFTDLVHGSYQMNIFEDNAELISLYQAMDNIKNRFGKDAVGRAVGFNFLR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR134289
EMBL· GenBank· DDBJ
VEE11161.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp