A0A3S4KWI9 · A0A3S4KWI9_AVIVO

Function

function

Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site159Proton donor
Binding site274-276CTP (UniProtKB | ChEBI)
Binding site280CTP (UniProtKB | ChEBI)
Binding site290CTP (UniProtKB | ChEBI)
Binding site308-311CTP (UniProtKB | ChEBI)
Binding site327CTP (UniProtKB | ChEBI)
Binding site341CTP (UniProtKB | ChEBI)
Binding site345CTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular Functionphosphopantothenate--cysteine ligase activity
Molecular Functionphosphopantothenoylcysteine decarboxylase activity
Biological Processcoenzyme A biosynthetic process
Biological Processpantothenate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Alternative names
    • DNA/pantothenate metabolism flavoprotein
    • Phosphopantothenoylcysteine synthetase/decarboxylase
      (PPCS-PPCDC
      )

Including 2 domains:

  • Recommended name
    Phosphopantothenoylcysteine decarboxylase
  • EC number
  • Short names
    PPC decarboxylase
    ; PPC-DC
  • Alternative names
    • CoaC
  • Recommended name
    Phosphopantothenate--cysteine ligase
  • EC number
  • Alternative names
    • CoaB
    • Phosphopantothenoylcysteine synthetase
      (PPC synthetase
      ; PPC-S
      )

Gene names

    • Name
      coaBC
    • ORF names
      NCTC3438_00721

Organism names

Accessions

  • Primary accession
    A0A3S4KWI9

Proteomes

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-191Phosphopantothenoylcysteine decarboxylase
Domain7-177Flavoprotein
Domain189-370DNA/pantothenate metabolism flavoprotein C-terminal
Region192-403Phosphopantothenate--cysteine ligase

Sequence similarities

In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    403
  • Mass (Da)
    43,284
  • Last updated
    2019-04-10 v1
  • Checksum
    B3FCFB4782547531
MQDLQGKRIVVGITGGIAAYKSIELIRLLRKSQAEVRVVLTPAAAEFVTPLTLQAISGNAVAQSLLDPQAELAMGHIELAKWADLIVIAPASADFMARLNAGMANDLLTTICLATAAPILLAPAMNQQMFRQPITQQNLASLKARGIATIGPNSGEQACGDMGFGRMSEPQEIYTALCEILLPPQDLSHLTIAITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGAKVKLIAGPVNLPTPAQVERIEVISAQEMANASLSLAPQVDIFIGCAAVADYRVAQIAEQKMKKTADRDTLTLELVKNPDIIAAVAALTEHRPFVVGFAAETQNVAQYAQDKLVRKNLDLICANDVSNGQGFNGDDNQLQLFWHDGNVQLPRSHKKDLAVQLAQQIVERFQAQV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR134167
EMBL· GenBank· DDBJ
VEB22922.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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