A0A3S4J9Q2 · A0A3S4J9Q2_AVIVO

Function

function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site12-17ATP (UniProtKB | ChEBI)
Binding site16Mg2+ (UniProtKB | ChEBI)
Active site37
Binding site64ATP (UniProtKB | ChEBI)
Binding site64Mg2+ (UniProtKB | ChEBI)
Binding site122Mg2+ (UniProtKB | ChEBI)
Binding site182-183ATP (UniProtKB | ChEBI)
Binding site211-213ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiondethiobiotin synthase activity
Molecular Functionmagnesium ion binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent dethiobiotin synthetase BioD
  • EC number
  • Alternative names
    • DTB synthetase
      (DTBS
      )
    • Dethiobiotin synthase

Gene names

    • Name
      bioD1_1
    • Synonyms
      bioD
    • ORF names
      NCTC3438_01455

Organism names

Accessions

  • Primary accession
    A0A3S4J9Q2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    240
  • Mass (Da)
    26,819
  • Last updated
    2019-04-10 v1
  • Checksum
    25B99397B3446363
MSCFFVTGTDTNVGKTVSSRAIIQALQNQGIQIVGYKPIACCQEDWSYCESTVDSDYGLENNSDVLTLIDATKENVTYQNVNSYSFSHSLPMLSEDGQRIDIKKINADLSALTQRYQSVLVEGAFGWLTPMNKEYSFASWAISHKMPVVLVVGIKEGCINHALLTAQSIQQSGLPLVGWIANRINPGLAHYAEIIEMLSKKIDAPLLGQIPYVHRPEEQELGHYITNIERLTYLQTEWVK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR134167
EMBL· GenBank· DDBJ
VEB24315.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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