A0A3S4J9Q2 · A0A3S4J9Q2_AVIVO
- ProteinATP-dependent dethiobiotin synthetase BioD
- GenebioD1_1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids240 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Catalytic activity
- (7R,8S)-7,8-diammoniononanoate + CO2 + ATP = (4R,5S)-dethiobiotin + ADP + phosphate + 3 H+
Cofactor
Pathway
Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12-17 | ATP (UniProtKB | ChEBI) | |||
Binding site | 16 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 37 | ||||
Binding site | 64 | ATP (UniProtKB | ChEBI) | |||
Binding site | 64 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 122 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 182-183 | ATP (UniProtKB | ChEBI) | |||
Binding site | 211-213 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | dethiobiotin synthase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | biotin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent dethiobiotin synthetase BioD
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Avibacterium
Accessions
- Primary accessionA0A3S4J9Q2
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length240
- Mass (Da)26,819
- Last updated2019-04-10 v1
- Checksum25B99397B3446363
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LR134167 EMBL· GenBank· DDBJ | VEB24315.1 EMBL· GenBank· DDBJ | Genomic DNA |