A0A3S4ICC4 · A0A3S4ICC4_AVIVO
- ProteinSuccinyl-diaminopimelate desuccinylase
- GenedapE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
Catalytic activity
- N-succinyl-(2S,6S)-2,6-diaminoheptanedioate + H2O = (2S,6S)-2,6-diaminoheptanedioate + succinate
Cofactor
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Note: Binds 2 Zn2+ or Co2+ ions per subunit.
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 67 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Active site | 69 | ||||
Binding site | 100 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 100 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Active site | 134 | Proton acceptor | |||
Binding site | 135 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 163 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 349 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | cobalt ion binding | |
Molecular Function | succinyl-diaminopimelate desuccinylase activity | |
Molecular Function | zinc ion binding | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinyl-diaminopimelate desuccinylase
- EC number
- Short namesSDAP desuccinylase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Avibacterium
Accessions
- Primary accessionA0A3S4ICC4
Proteomes
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)41,458
- Last updated2019-04-10 v1
- ChecksumD322B7B31ECEC74E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LR134167 EMBL· GenBank· DDBJ | VEB23594.1 EMBL· GenBank· DDBJ | Genomic DNA |