A0A3S4IC78 · A0A3S4IC78_CHRVL
- ProteinBifunctional ligase/repressor BirA
- GenebirA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids557 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
Catalytic activity
- (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H+
Cofactor
Protein has several cofactor binding sites:
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Features
Showing features for dna binding, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 20-39 | H-T-H motif | ||||
Sequence: GEDIAQALGCSRTLVWQAVR | ||||||
Binding site | 93-95 | biotin (UniProtKB | ChEBI) | ||||
Sequence: STN | ||||||
Binding site | 117 | biotin (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 121-123 | biotin (UniProtKB | ChEBI) | ||||
Sequence: RGR | ||||||
Binding site | 187 | biotin (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | biotin-[acetyl-CoA-carboxylase] ligase activity | |
Molecular Function | DNA binding | |
Molecular Function | pantothenate kinase activity | |
Biological Process | coenzyme A biosynthetic process | |
Biological Process | protein modification process | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional ligase/repressor BirA
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Chromobacteriaceae > Chromobacterium
Accessions
- Primary accessionA0A3S4IC78
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 69-254 | BPL/LPL catalytic | ||||
Sequence: AAIRAGLSPAAAEAFTLAVAERTDSTNSQLMVRAGNGGLHGLVLACELQTAGRGRLGRRWQARLGSGLTFSLLWRFERGLAELAGLSLAIGVALGRALRTLGAPVELKWPNDVLLEGRKLAGILIEVSGDALGPAAAVVGIGLNVADPGAVDQPVAALEQAGVAPDRNRVLSAMLNELERVLADFD | ||||||
Region | 320-340 | Disordered | ||||
Sequence: ANEIADRRRQQPGEMGAVPGR |
Sequence similarities
Belongs to the biotin--protein ligase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length557
- Mass (Da)58,362
- Last updated2019-04-10 v1
- Checksum7A730E54D98F43EB