A0A3S4IC78 · A0A3S4IC78_CHRVL

  • Protein
    Bifunctional ligase/repressor BirA
  • Gene
    birA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

NH4+ (UniProtKB | Rhea| CHEBI:28938 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Features

Showing features for dna binding, binding site.

TypeIDPosition(s)Description
DNA binding20-39H-T-H motif
Binding site93-95biotin (UniProtKB | ChEBI)
Binding site117biotin (UniProtKB | ChEBI)
Binding site121-123biotin (UniProtKB | ChEBI)
Binding site187biotin (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionbiotin-[acetyl-CoA-carboxylase] ligase activity
Molecular FunctionDNA binding
Molecular Functionpantothenate kinase activity
Biological Processcoenzyme A biosynthetic process
Biological Processprotein modification process
Biological Processregulation of DNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional ligase/repressor BirA
  • Alternative names
    • Biotin--[acetyl-CoA-carboxylase] ligase
      (EC:6.3.4.15
      ) . EC:6.3.4.15 (UniProtKB | ENZYME | Rhea)
    • Biotin--protein ligase
    • Biotin-[acetyl-CoA carboxylase] synthetase

Gene names

    • Name
      birA
    • ORF names
      NCTC9695_00667

Organism names

  • Taxonomic identifier
  • Strain
    • NCTC9695
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Chromobacteriaceae > Chromobacterium

Accessions

  • Primary accession
    A0A3S4IC78

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain69-254BPL/LPL catalytic
Region320-340Disordered

Sequence similarities

Belongs to the biotin--protein ligase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    557
  • Mass (Da)
    58,362
  • Last updated
    2019-04-10 v1
  • Checksum
    7A730E54D98F43EB
MSEHAFAVLRHLSDGRFHSGEDIAQALGCSRTLVWQAVRTIESELGLTVFSVRGQGYKLAQPFGWLDVAAIRAGLSPAAAEAFTLAVAERTDSTNSQLMVRAGNGGLHGLVLACELQTAGRGRLGRRWQARLGSGLTFSLLWRFERGLAELAGLSLAIGVALGRALRTLGAPVELKWPNDVLLEGRKLAGILIEVSGDALGPAAAVVGIGLNVADPGAVDQPVAALEQAGVAPDRNRVLSAMLNELERVLADFDRDGFAPLRDEWWRLCAHRDAPVRLSFSHGEPVDGVACGVAENGALLAQTAQGRGLSISARSVSGSANEIADRRRQQPGEMGAVPGRGLRAAGRGRAWRAGRLGRGLARSAAGGAWMSSVARREVADALAAAVPCPLHRVHAERRFGDVRNHYCNTAEQGADRWLAVLAARELCRGDVIVACAGTALTVEALTAEGDYLGGLILPGHGLMLQSLAQGTANLNRPAGEVVDFPQGTQDALASGAIAALAGAIAEQRRRLAERTGRAPATVILTGGDAARIAPWLAAPMQIVDNLVLMGLLKVANT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR134182
EMBL· GenBank· DDBJ
VEB40271.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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