A0A3S4H4P3 · A0A3S4H4P3_AVIVO

Function

function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.

Catalytic activity

  • Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
    EC:3.4.21.92 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

120020406080100120140160180200
TypeIDPosition(s)Description
Active site102
Active site102Nucleophile
Active site127

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendopeptidase Clp complex
Molecular FunctionATP-dependent peptidase activity
Molecular FunctionATPase binding
Molecular Functionserine-type endopeptidase activity
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent Clp protease proteolytic subunit
  • EC number
  • Alternative names
    • Endopeptidase Clp

Gene names

    • Name
      clpP
    • ORF names
      NCTC3438_00772

Organism names

Accessions

  • Primary accession
    A0A3S4H4P3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

Family & Domains

Sequence similarities

Belongs to the peptidase S14 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    22,273
  • Last updated
    2019-04-10 v1
  • Checksum
    E90DA06E6DD4D425
MENTMALIPMVVEQTARGERSYDIYSRLLKERIIFLSGQVEDNMANLIVAQLLFLESENPDKDISLYINSPGGVVTAGMAIYDTMQFIKPDVRTLCIGQACSMGAFLLAGGAPGKRAALPNARVMIHQPLGGYRGQASDIQIHAQEILKIKHTLNERLAFHTGQPFEKVEQDTDRDNFMTAEEAKLYGLIDEVLVKRETE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR134167
EMBL· GenBank· DDBJ
VEB23017.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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