A0A3S3NCA4 · A0A3S3NCA4_9MAGN
- Protein4-hydroxy-4-methyl-2-oxoglutarate aldolase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids171 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
Catalytic activity
- 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxaloacetate decarboxylase activity | |
Molecular Function | ribonuclease inhibitor activity | |
Biological Process | regulation of RNA metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-4-methyl-2-oxoglutarate aldolase
- EC number
- Short namesHMG aldolase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Magnoliidae > Laurales > Lauraceae > Cinnamomum
Accessions
- Primary accessionA0A3S3NCA4
Proteomes
Interaction
Structure
Sequence
- Sequence statusComplete
- Length171
- Mass (Da)18,567
- Last updated2019-04-10 v1
- Checksum7C36E6610AEFDC19
Keywords
- Technical term