A0A3S3NCA4 · A0A3S3NCA4_9MAGN

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site81-84substrate
Binding site103substrate
Binding site104Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase

Gene names

    • ORF names
      CKAN_01360200

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Chaw 1501
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Magnoliidae > Laurales > Lauraceae > Cinnamomum

Accessions

  • Primary accession
    A0A3S3NCA4

Proteomes

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    171
  • Mass (Da)
    18,567
  • Last updated
    2019-04-10 v1
  • Checksum
    7C36E6610AEFDC19
MAAFATADICDANERLLESGDLRILHPVFKIYGRSQAFFGPIVTIKVFEENLLVKELLEAGGEGRVLMIDGGGSMRRGMVGGYLAQLAKNMGWSGILVNGCVRDVEEINACDIGIRALASVPRRCNKNRIGEIHVPVHIGDALIRDGEWLYADSDGILISKTELSITPAKN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QPKB01000005
EMBL· GenBank· DDBJ
RWR84776.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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