A0A3S2UP71 · A0A3S2UP71_ORYJA

Function

function

Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains.

Catalytic activity

  • (5Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • oxidized [electron-transfer flavoprotein] + (9Z)-octadecenoyl-CoA + H+ = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H+ = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • octanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
    EC:1.3.8.8 (UniProtKB | ENZYME | Rhea)
  • decanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.
  • eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]
    This reaction proceeds in the forward direction.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Lipid metabolism; mitochondrial fatty acid beta-oxidation.

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionlong-chain fatty acyl-CoA dehydrogenase activity
Biological Processlong-chain fatty acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Long-chain specific acyl-CoA dehydrogenase, mitochondrial
  • EC number

Gene names

    • ORF names
      OJAV_G00014750

Organism names

  • Taxonomic identifier
  • Strain
    • RS831
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3S2UP71

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-142Acyl-CoA dehydrogenase/oxidase N-terminal
Domain146-243Acyl-CoA oxidase/dehydrogenase middle
Domain255-403Acyl-CoA dehydrogenase/oxidase C-terminal

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    407
  • Mass (Da)
    45,767
  • Last updated
    2019-04-10 v1
  • Checksum
    C6F9C48567A57451
MQDLDSHASPSRLETSNAKTMMDIGTRRIFNEDHDIFRQSVRRFFQEEVVPHHKEWEKAGQVSRELWEKAGEQGLLGVMIPEEHGGIGGDVFSAAITWEEQMYCNCTGPGFTLHSDVVMPYIVNYGSKEQVERFIPNMTAGKCITAIAMTEPGAGSDLQGVRTYAKKDGNDWILNGNKVFISNGWMADLVVVVTVTNREAKTAAHGISLFLVEDGMKGFQKGRKLDKIGLKAQDTAELFFKDVRLPASALLGELNKGFYYLMNELPQERLLIADMAIASCEFMFEETRNYVLQRKAFGKTISHLQTVQHKLAELKTEICVGRTFVDNCLQLLSEKRLDPSTASMAKFWASELQNKVASQCLQLHGGWGYMWEYPIAKAFVDSRVQPIYGGTNEIMKELIARSIVSQK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM012438
EMBL· GenBank· DDBJ
RVE75232.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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