A0A3S2UP71 · A0A3S2UP71_ORYJA
- ProteinLong-chain specific acyl-CoA dehydrogenase, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids407 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains.
Catalytic activity
- (5Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- oxidized [electron-transfer flavoprotein] + (9Z)-octadecenoyl-CoA + H+ = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H+ = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- octanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- decanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; mitochondrial fatty acid beta-oxidation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | long-chain fatty acyl-CoA dehydrogenase activity | |
Biological Process | long-chain fatty acid catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLong-chain specific acyl-CoA dehydrogenase, mitochondrial
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionA0A3S2UP71
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 31-142 | Acyl-CoA dehydrogenase/oxidase N-terminal | ||||
Sequence: NEDHDIFRQSVRRFFQEEVVPHHKEWEKAGQVSRELWEKAGEQGLLGVMIPEEHGGIGGDVFSAAITWEEQMYCNCTGPGFTLHSDVVMPYIVNYGSKEQVERFIPNMTAGK | ||||||
Domain | 146-243 | Acyl-CoA oxidase/dehydrogenase middle | ||||
Sequence: AIAMTEPGAGSDLQGVRTYAKKDGNDWILNGNKVFISNGWMADLVVVVTVTNREAKTAAHGISLFLVEDGMKGFQKGRKLDKIGLKAQDTAELFFKDV | ||||||
Domain | 255-403 | Acyl-CoA dehydrogenase/oxidase C-terminal | ||||
Sequence: NKGFYYLMNELPQERLLIADMAIASCEFMFEETRNYVLQRKAFGKTISHLQTVQHKLAELKTEICVGRTFVDNCLQLLSEKRLDPSTASMAKFWASELQNKVASQCLQLHGGWGYMWEYPIAKAFVDSRVQPIYGGTNEIMKELIARSI |
Sequence similarities
Belongs to the acyl-CoA dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length407
- Mass (Da)45,767
- Last updated2019-04-10 v1
- ChecksumC6F9C48567A57451
Keywords
- Technical term