A0A3S2PF72 · A0A3S2PF72_ORYJA

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      OJAV_G00190300

Organism names

  • Taxonomic identifier
  • Strain
    • RS831
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3S2PF72

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-29Helical
Transmembrane70-90Helical
Transmembrane97-119Helical
Transmembrane160-181Helical
Transmembrane193-215Helical
Transmembrane248-267Helical
Transmembrane287-309Helical
Transmembrane315-336Helical
Transmembrane343-360Helical
Transmembrane372-391Helical
Transmembrane412-433Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain11-437Major facilitator superfamily (MFS) profile
Region443-479Disordered
Compositional bias449-469Basic and acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    479
  • Mass (Da)
    52,563
  • Last updated
    2019-04-10 v1
  • Checksum
    81E63CD1D97ADAA6
MVQPAEKAYYRFVVLFFNCLLTFGSYFCFDMPSVLQDQFQGNLTCSNATVINGTVDCVAGLGMTPQQYNLLYAIYAWTNAIVVILAGFLIDKLGNRFGVFLFSFLCVLGSSLFALGSHFKGTPYLLPLMLTGRLLFGSGNGSLTIVQNRITAFWFKGKELALAFGVTLAFSRLGSVLNFFLTEKFEDKFGMQWTLWGGALLCVLGFSSAIIVSAMDKVGMKQLGLEGSMQEASRKVRIQDVKLLSLRYWLLVLTIMFFYNGIFPFIADASKFIQDKYGNYSQKEAAYVAGAVYDSSLVLSASVGILIYYVGLRGIFALTCAVLTLPVFGLLAFTFVPPLVSTIWLGITYSFAAASMWPSIPLVVPQATLGTAMGLATSIQMVGIGLSNLVVGQILGTQSSEAKIPLWRWKRMMIFMLANTVSCIVTSVLLNVVDYKQGGTLNKTTKRSQQAERNSEREPLIKAEEEQNEDDGAANSINS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias449-469Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM012455
EMBL· GenBank· DDBJ
RVE59607.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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