A0A3S2PCC9 · A0A3S2PCC9_ORYJA

Function

function

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.

Catalytic activity

GO annotations

AspectTerm
Cellular ComponentCOPII vesicle coat
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum exit site
Cellular Componentendoplasmic reticulum membrane
Cellular Componentsignal recognition particle, endoplasmic reticulum targeting
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activator activity
Molecular FunctionGTPase activity
Molecular Functionzinc ion binding
Biological ProcessCOPII-coated vesicle cargo loading
Biological Processintracellular protein transport
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein transport protein Sec23A
  • EC number
  • Alternative names
    • SEC23-related protein A
    • Signal recognition particle 54 kDa protein
    • Signal recognition particle subunit SRP54

Gene names

    • ORF names
      OJAV_G00218580

Organism names

  • Taxonomic identifier
  • Strain
    • RS831
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3S2PCC9

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain350-363SRP54-type proteins GTP-binding

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.
Belongs to the SEC23/SEC24 family. SEC23 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,367
  • Mass (Da)
    152,721
  • Last updated
    2019-04-10 v1
  • Checksum
    CC3BFB1D0B48146A
MIRRWMDRWMMAARPPAVLRPPAPQGALLFDVSLTRVWFCCCWIELFIARRGAVCGSQLITERAQWGWSCLLSHRPLQTAAMVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCAALLEADVNIKLVKQLRENVKAAIDLEEMASGLNKRRMIQHAVFKELVKLVDPGVKAWTPTKGKNNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVVIAAEGVDKFKAENFEIIIVDTSGRHKQEDSLFEEMLQVSNAVQPDNIVYVMDASIGQACESQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATRSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDRVNELKLDDNEELIDKLKHGQFTLRDMYEQFQNIMKMGPFGQIMGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSKDGAKLFSKQPNRIQRVARGSGVATRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVNPSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNMSNDPERSLCPLLPPPRVAMATFAEYIAQNEERDGIRFSWNVWPSSRLEATRMVVPVAALFTPLKERMDLPPIQYEPVLCSRATCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAGISEVNQPAELLPHFSTIEYVVQRGPQMPLVFLYVVDTCMDDEDLQALKDSLQMSLSLLPPTTLVGLITFGRMVQVHELGCQGISKSYVFRGTKDLSAKQLQEMLGLAKPSAAQNRGPQGAAPPPTNRFLQPVQKIDMSMMDLLSGLQRDPWPVTQGKRPLRSLGVAMSIAVGLLECTFPNAGARIMTFIGGPATQGPGMVVGDELKTPIRSWHDIEKDNAKFMKKATKHFESLANRAAANGHIIDIYACALDQTGLLEMKCCPNHTGGYMVMADSFNTALFNQTFQKVFSKDVQGSFRMAFSGTLEVKTSREIKVSGAIGPCVTLNAKGPCVSENEIGTGGTSQWKICGLDPSTTLALYFEIVNQHNAPIPQGGRGAIQFVTQYQHSSGQRRIRVTTTARNWADAQTQIQSIAASFDQEAAAVLMARLAVYRAETEEGPDVLRWLDRQLIRLCQKFGDYHKDDPNSFRFSETFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFNRQDLTQALIMIQPVLYAYSFNGPPEPVLLDSSSILPDRILLMDTFFQILIYHGETVAQWRKAGYQNMPEYENFQKLLDAPQDDARELLHTRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYTWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM012458
EMBL· GenBank· DDBJ
RVE57657.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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