A0A3S2P2X3 · A0A3S2P2X3_ORYJA
- ProteinPoly [ADP-ribose] polymerase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1015 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
Catalytic activity
- L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamideThis reaction proceeds in the forward direction.
- L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamideThis reaction proceeds in the forward direction.
- L-histidyl-[protein] + NAD+ = H+ + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamideThis reaction proceeds in the forward direction.
- L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]This reaction proceeds in the forward direction.
- L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | NAD binding | |
Molecular Function | NAD+ ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein-histidine ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein-serine ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein-tyrosine ADP-ribosyltransferase activity | |
Molecular Function | nucleotidyltransferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA repair | |
Biological Process | regulation of circadian sleep/wake cycle, sleep |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePoly [ADP-ribose] polymerase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionA0A3S2P2X3
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 10-92 | PARP-type | ||||
Sequence: FRAEYAKSGQASCKKCKEKIAKESLRMAIVVQSPMFDGKVPHWHHFSCFWQRASVQSTADVGGFSDLRWADQEAVKKAIESGG | ||||||
Domain | 114-204 | PARP-type | ||||
Sequence: FAVEYAKSNRSTCKGCQQKIEKDQIRVSKKVVDPEKPQLGLIDRWYHTACFVSSREELAFKPNYSAAQLKGFNALRAEDKEELKKRLPAVK | ||||||
Region | 199-225 | Disordered | ||||
Sequence: RLPAVKTEGKRPGDELDGVSKKLKQEE | ||||||
Region | 357-393 | Disordered | ||||
Sequence: KEAPTQTVTTAKGEPLASGSGALKEPLPEGAPSDKPL | ||||||
Domain | 388-464 | BRCT | ||||
Sequence: PSDKPLTGMKLLAVGKLSKNKEELKTEVEEMGGKITGTANKASLCLSTKKEVEKMGKKMEEIRDAGVRVVSEDFLRD | ||||||
Region | 495-527 | Disordered | ||||
Sequence: PAAASKSGALAAKSTGRVKEEEGGNKSKKMKLT | ||||||
Compositional bias | 509-523 | Basic and acidic residues | ||||
Sequence: TGRVKEEEGGNKSKK | ||||||
Domain | 543-639 | WGR | ||||
Sequence: SAHVLEQSGKMYSATLGLVDIVRGTNSYYKLQLLEDDLHKRYWVFRSWGRVGTTIGGNKLDKFHDKNSALDNFLSVYKEKTGNEWGSSNFIKYPTKF | ||||||
Domain | 663-780 | PARP alpha-helical | ||||
Sequence: KSKLAKPVQELIKMIFDVESMKKAMVEFEIDLQKMPLGKLSKRQIQSAYALLTEVQQAVSDCVPEAQILDLSNRFYTLIPHDFGMKKPPLLNSLDYIQAKVEMLDNLLDIEVAYSLLR | ||||||
Domain | 789-1015 | PARP catalytic | ||||
Sequence: DPIDINYEKLKTKIEVVDKSSQEAEVITQYVKNTHAATHNTYTLEVQEIFKIGREGERQRFRPFEELHNRQLLWHGSRTTNYAGIMSQGLRIAPPEAPVTGYMFGKGVYFADMVSKSANYCHTSQSDPVGLLLLAEVALGNMHELKKASHITKLPKGKHSVKGLGRTAPDPNATVTLDGVQVPLGKGVQTNIDDTSLLYNEYIVYDVAQINLKYLLKIKFNYQTSLW |
Sequence similarities
Belongs to the ARTD/PARP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,015
- Mass (Da)112,866
- Last updated2019-04-10 v1
- Checksum6F252885537EE33E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 509-523 | Basic and acidic residues | ||||
Sequence: TGRVKEEEGGNKSKK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM012460 EMBL· GenBank· DDBJ | RVE55796.1 EMBL· GenBank· DDBJ | Genomic DNA |