A0A3S2N596 · A0A3S2N596_ORYJA

Function

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionIMP cyclohydrolase activity
Molecular Functionphosphoribosylaminoimidazolecarboxamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional purine biosynthesis protein ATIC
  • EC number
  • Alternative names
    • AICAR transformylase/inosine monophosphate cyclohydrolase

Gene names

    • ORF names
      OJAV_G00021220

Organism names

  • Taxonomic identifier
  • Strain
    • RS831
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3S2N596

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-146MGS-like

Sequence similarities

Belongs to the PurH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    591
  • Mass (Da)
    64,057
  • Last updated
    2019-04-10 v1
  • MD5 Checksum
    F81EC32F3E77B9EA7EFF712F34D5FC66
MASSELALLSVSDKAGLVDFSRRLVGAGLSLVASGGTAKALRDAGLAVRDVSELTGHPEMLGGRVKTLHPAVHGGILARRTPSDAADMDKLGYSLVRVVVCNLYPFVKTVSSPDVTVEDAVEQIDIGGVTLLRAAAKNHARVTIVCDPDDYSVVAKEMESSSDKDTTLETRKTLALKAFTHTAQYDEAISDYFRGQYSRGVSQLPLRYGMNPHQAPAQLYTLRPELPLTVINGSPGFINLCDALNAWQLVRELKSALGVAAATSFKHVSPAGAAVGVPLTEEEAKVCMVHDMLSDLTPLATAYARARGSDRMSSFGDFIALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGNYCVLQMDPDYEPDDTEVRVLFGLFLKQKRNGALINKDFFTNVVSNGSLSNEAVRDLTVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKADNWWLRHHPRVLNMNFRSGVKRAEMANCIDQYVSNTIGEGPDLAVWKSMYEEVPEPLSHTEKKNWISSLQAVAVSSDAFFPFRDNIDRAKRSGVEYIAAPAGSAADQVVINACNEQGITLVHTNLRLFHH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM012439
EMBL· GenBank· DDBJ
RVE74354.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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