A0A3S0ZT07 · A0A3S0ZT07_ELYCH

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = a fatty acid + glycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoate
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functionacylglycerol lipase activity
Molecular Functionhormone-sensitive lipase activity
Molecular Functionsterol esterase activity
Molecular Functiontriglyceride lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Gene names

    • ORF names
      EGW08_006196

Organism names

Accessions

  • Primary accession
    A0A3S0ZT07

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-325Hormone-sensitive lipase N-terminal
Domain358-477Alpha/beta hydrolase fold-3
Domain574-639Alpha/beta hydrolase fold-3

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    663
  • Mass (Da)
    73,702
  • Last updated
    2019-04-10 v1
  • Checksum
    7EDE65F96B8D9641
MMEFDSTDNPGRFFFALSKDLKSIALSNIQFFKSGKQSNHAKFHVLFRLLYEYLDIGIEPTYAELSKLVSEYDYSPEIKGNGYRSLLRVVQKCCLHLLQLCRYISTVRDSMLFRKKVYAKELESYVSALGQLRAVLYYALKLTQYCQRGHLFADEDQLNSDIAEALMIEVESLSQEYFYGRCLGFQYCESMQRPVQAIGIVMASLSEGYLESSQVMRVATSVFNSGKYFLDPELRAKQMVKVTRTADIRFCQTFWNFPESPIMHQLPSFVCPMMEVNEMLTLGPDAFELPSVDGGETVTITPPCAHTGPGHVYTRLISAQLRDGQVGSEYICSYNDSLTKSVKSKGPVSAKPRVPGLVVHFHGGGFVAQSSKSHEVYLRDWAVSLDCPILSVDYSLAPQAPFPRALEECFYAYAWAVQNCEQLGSTGEKIIVVGDSAGGNLAISTAMRAASFGIRPPDGAVLVYPCTVVKYTPSPARLLSLMDPLLPVGLMTRCLAGEEVCGSSPTLATSSPTGWVGVSIIRTPPTPPVISNICFYENDRNCQIIYLNLEEMPTSTFEVQNFSSHSPLHLLRRAAVVKNPYMSPLMASDEMLAGLTRVSIIGCHLDPLLDDSVMMARRLRDLGVPVDLHLVDDLPHGFLNFALLSMEARQAADLCGRKIRDML

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue663

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RQTK01000152
EMBL· GenBank· DDBJ
RUS86042.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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