A0A3S0P5L2 · A0A3S0P5L2_9BACI

  • Protein
    Holliday junction resolvase RecU
  • Gene
    recU
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
    EC:3.1.21.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site92Mg2+ (UniProtKB | ChEBI)
Binding site94Mg2+ (UniProtKB | ChEBI)
Binding site107Mg2+ (UniProtKB | ChEBI)
Site109Transition state stabilizer
Binding site126Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionendonuclease activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Biological Processchromosome segregation
Biological ProcessDNA recombination
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Holliday junction resolvase RecU
  • EC number
  • Alternative names
    • Recombination protein U homolog

Gene names

    • Name
      recU
    • ORF names
      EK386_04050

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SYSU K30002
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Lysinibacillus

Accessions

  • Primary accession
    A0A3S0P5L2

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the RecU family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    209
  • Mass (Da)
    24,477
  • Last updated
    2019-04-10 v1
  • Checksum
    FBE5615B779AA43B
MVIRYPNGKQFKSNSNEMTEKKKRIIKKEKDISFSNRGKTLEDEINDTNIYYLNQQIAIIHKKPVPVQIVKVEYPSRSAAVIREAYFRTPSTTDYNGVWNGYYIDFEAKETENRTSFPLKNVHQHQVTHMQQVTNQKGIAFTIVRFSSLDRYFVVPFNILYEAWTTMENGGRKSIPLNVFETKTFEIKPGYNPKIDYLSVMTNLIVNEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RYYR01000004
EMBL· GenBank· DDBJ
RUL55507.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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