A0A3S0JPS0 · A0A3S0JPS0_STEMA

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site78Nucleophile
Active site179
Active site181

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutaminase activity
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionlyase activity
Biological Processglutamine metabolic process
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisH
  • EC number
  • Alternative names
    • IGP synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)
    • IGP synthase subunit HisH
    • ImGP synthase subunit HisH
      (IGPS subunit HisH
      )

Gene names

    • Name
      hisH
    • ORF names
      EKL94_03955

Organism names

Accessions

  • Primary accession
    A0A3S0JPS0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of HisH and HisF.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-195Glutamine amidotransferase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    21,343
  • Last updated
    2019-04-10 v1
  • Checksum
    D9F22D1F6DC7B45D
MSDVALIDAGGANLGSVRYALERLGATVRLVRDADGLVGAQRVILPGVGAAGPGMQRLHAQGLVEPLQRLEVPLMGICLGMQLLFERSEEAGVETLGLIPGVVRKLVPACGIRVPHMGWNRLLPLRESLLLRGVPERASAYFVHSYAAPLNTYTVAACDHGGLFTAVVEQGRYYGAQFHPERSGETGSLMLRNFLEGTAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RXLZ01000007
EMBL· GenBank· DDBJ
RTQ91287.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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