A0A3R9A4A5 · A0A3R9A4A5_ENTCL
- ProteinProtein translocase subunit SecA
- GenesecA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids901 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Catalytic activity
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell envelope Sec protein transport complex | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | intracellular protein transmembrane transport | |
Biological Process | protein import | |
Biological Process | protein targeting | |
Biological Process | protein transport by the Sec complex |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein translocase subunit SecA
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex
Accessions
- Primary accessionA0A3R9A4A5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Note: Distribution is 50-50.
Keywords
- Cellular component
Expression
Induction
Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.
Interaction
Subunit
Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-619 | SecA family profile | ||||
Sequence: IKLLTKVFGSRNDRTLRRMRKAVAVINGMEPAMEKLSDDELKAKTAEFRARLEKGETLESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMTVGINMSGLPAPAKREAYNADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSDMYRKVDKIIPHLLRQEKEDSDTFQGEGHFSVDEKARQVNLTERGLVKIEELLVAEGIMEEGESLYSPSNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVDIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDMPDLVYMTEAEKIQAIIEDIRERTAKGQPVLVGTISIEKSEVVSNELTKAGIKHNVLNAKFHAKEADIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAELENPTPEQIAQIKADWQVRHDAVLASGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIE | ||||||
Domain | 89-247 | Helicase ATP-binding | ||||
Sequence: LGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMTVGINMSGLPAPAKREAYNADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSDMYRKVDKIIPHLL | ||||||
Domain | 434-635 | Helicase C-terminal | ||||
Sequence: KIQAIIEDIRERTAKGQPVLVGTISIEKSEVVSNELTKAGIKHNVLNAKFHAKEADIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAELENPTPEQIAQIKADWQVRHDAVLASGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVE | ||||||
Region | 856-891 | Disordered | ||||
Sequence: QLSHQTDDSEAAAAIAAQTGDRKVGRNDPCPCGSGK |
Sequence similarities
Belongs to the SecA family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length901
- Mass (Da)101,962
- Last updated2019-04-10 v1
- Checksum253540C056BEF2C9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DADOIZ010000007 EMBL· GenBank· DDBJ | HAZ4814725.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCIY010000009 EMBL· GenBank· DDBJ | MDH1478859.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RHWT01000010 EMBL· GenBank· DDBJ | RSB31147.1 EMBL· GenBank· DDBJ | Genomic DNA |