A0A3R9A4A5 · A0A3R9A4A5_ENTCL

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1901100200300400500600700800900
TypeIDPosition(s)Description
Binding site87ATP (UniProtKB | ChEBI)
Binding site105-109ATP (UniProtKB | ChEBI)
Binding site512ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      EGK68_09680
      , J5T73_002949
      , N5E88_05030

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • C041
    • EC_073
    • GD03711
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex

Accessions

  • Primary accession
    A0A3R9A4A5

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Note: Distribution is 50-50.

Keywords

Expression

Induction

Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain3-619SecA family profile
Domain89-247Helicase ATP-binding
Domain434-635Helicase C-terminal
Region856-891Disordered

Sequence similarities

Belongs to the SecA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    901
  • Mass (Da)
    101,962
  • Last updated
    2019-04-10 v1
  • Checksum
    253540C056BEF2C9
MLIKLLTKVFGSRNDRTLRRMRKAVAVINGMEPAMEKLSDDELKAKTAEFRARLEKGETLESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMTVGINMSGLPAPAKREAYNADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSDMYRKVDKIIPHLLRQEKEDSDTFQGEGHFSVDEKARQVNLTERGLVKIEELLVAEGIMEEGESLYSPSNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVDIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDMPDLVYMTEAEKIQAIIEDIRERTAKGQPVLVGTISIEKSEVVSNELTKAGIKHNVLNAKFHAKEADIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAELENPTPEQIAQIKADWQVRHDAVLASGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSETINSIREDVFKATIDAHIPPQSLEEMWDIEGLQERLKNDFDLDLPIKEWLDKEPELHEETLRERIYETALEVYKRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFASMLESLKYEVISTLSKVQVRMPEEVEAMEQQRREEAERLAQMQQLSHQTDDSEAAAAIAAQTGDRKVGRNDPCPCGSGKKYKACHGRLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DADOIZ010000007
EMBL· GenBank· DDBJ
HAZ4814725.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCIY010000009
EMBL· GenBank· DDBJ
MDH1478859.1
EMBL· GenBank· DDBJ
Genomic DNA
RHWT01000010
EMBL· GenBank· DDBJ
RSB31147.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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