A0A3R7FIH4 · A0A3R7FIH4_9EURY
- ProteinTritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
- GeneuppS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids308 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
Catalytic activity
- geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate
Cofactor
Note: Binds 2 magnesium ions per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 37 | |||||
Sequence: D | ||||||
Binding site | 37 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 38-41 | substrate | ||||
Sequence: GNRR | ||||||
Binding site | 50 | substrate | ||||
Sequence: K | ||||||
Binding site | 54 | substrate | ||||
Sequence: H | ||||||
Binding site | 82-84 | substrate | ||||
Sequence: STE | ||||||
Active site | 85 | Proton acceptor | ||||
Sequence: N | ||||||
Binding site | 86 | substrate | ||||
Sequence: F | ||||||
Binding site | 88 | substrate | ||||
Sequence: R | ||||||
Binding site | 207 | substrate | ||||
Sequence: R | ||||||
Binding site | 213-215 | substrate | ||||
Sequence: RTS | ||||||
Binding site | 226 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | prenyltransferase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloarculaceae > Haloarcula
Accessions
- Primary accessionA0A3R7FIH4
Proteomes
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length308
- Mass (Da)35,274
- Last updated2019-04-10 v1
- ChecksumC39107DC5076215E