A0A3R6QT65 · A0A3R6QT65_9CLOT
- ProteinMultifunctional fusion protein
- Genesmc
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1523 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Required for chromosome condensation and partitioning.
Catalytic activity
- GTP + H2O = GDP + phosphate + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Biological Process | chromosome condensation | |
Biological Process | chromosome segregation | |
Biological Process | DNA replication | |
Biological Process | sister chromatid cohesion | |
Biological Process | SRP-dependent cotranslational protein targeting to membrane |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended nameSignal recognition particle receptor FtsY
- EC number
- Short namesSRP receptor
- Recommended nameChromosome partition protein Smc
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionA0A3R6QT65
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.
Structure
Family & Domains
Features
Showing features for coiled coil, compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 167-254 | |||||
Sequence: IVKFKRRKAIAQKKLEDEKQNLIRVTDILSELEKQVGPLERQSEEAKEYLRLREELRCLDANLFLAESEELKRQIREVEQKEMILTGD | ||||||
Coiled coil | 325-422 | |||||
Sequence: MASIDGEMHQKEEEQAEYESEKQALNASVQMIEAKQQEAEAAVRSMDEAVSRTETLIETAKAEIMDALNQKAELAARRQRYETMLEQADVRRAEVTQK | ||||||
Compositional bias | 459-476 | Basic and acidic residues | ||||
Sequence: KELQEQTRTEEEQERRLN | ||||||
Region | 459-483 | Disordered | ||||
Sequence: KELQEQTRTEEEQERRLNQKLSSLQ | ||||||
Coiled coil | 672-793 | |||||
Sequence: LLGRRREIEELEAACKKALEQVEAVQKELAETGRRLTEAKRTLASVQERRQQMQIQQNTLELTICQLEARRQEIADSSQDLSSENQELELQVGDLRGALRELQTEETKLETLSNEKNQYVEE | ||||||
Coiled coil | 829-881 | |||||
Sequence: IEENLRRVLQEQERLRAEKEKLSGGHADSSETIAAREREIAALEAEIQASGDK | ||||||
Coiled coil | 910-937 | |||||
Sequence: KEELNERLQLLDRENFRLQNQRERLNER | ||||||
Coiled coil | 1005-1032 | |||||
Sequence: MKNQHEDLVAAQAALEKIIEELDEGMRR | ||||||
Domain | 1487-1500 | SRP54-type proteins GTP-binding | ||||
Sequence: PVKYVGIGEKIDDL |
Domain
Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
Sequence similarities
Belongs to the GTP-binding SRP family. FtsY subfamily.
Belongs to the SMC family. SMC3 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,523
- Mass (Da)172,150
- Last updated2019-04-10 v1
- ChecksumD180667B768BBC3A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 459-476 | Basic and acidic residues | ||||
Sequence: KELQEQTRTEEEQERRLN |