A0A3R6QT65 · A0A3R6QT65_9CLOT

  • Protein
    Multifunctional fusion protein
  • Gene
    smc
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Required for chromosome condensation and partitioning.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

115232004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site32-39ATP (UniProtKB | ChEBI)
Binding site1320-1327GTP (UniProtKB | ChEBI)
Binding site1402-1406GTP (UniProtKB | ChEBI)
Binding site1466-1469GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processchromosome condensation
Biological Processchromosome segregation
Biological ProcessDNA replication
Biological Processsister chromatid cohesion
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Signal recognition particle receptor FtsY
  • EC number
  • Short names
    SRP receptor
  • Recommended name
    Chromosome partition protein Smc

Gene names

    • Name
      smc
    • Synonyms
      ftsY
    • ORF names
      DW085_03180

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AF50-3
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium

Accessions

  • Primary accession
    A0A3R6QT65

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm

Keywords

Interaction

Subunit

Homodimer.
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

Family & Domains

Features

Showing features for coiled coil, compositional bias, region, domain.

TypeIDPosition(s)Description
Coiled coil167-254
Coiled coil325-422
Compositional bias459-476Basic and acidic residues
Region459-483Disordered
Coiled coil672-793
Coiled coil829-881
Coiled coil910-937
Coiled coil1005-1032
Domain1487-1500SRP54-type proteins GTP-binding

Domain

Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.

Sequence similarities

Belongs to the GTP-binding SRP family. FtsY subfamily.
Belongs to the SMC family. SMC3 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,523
  • Mass (Da)
    172,150
  • Last updated
    2019-04-10 v1
  • Checksum
    D180667B768BBC3A
MYLKSIEIQGFKSFANKILFEFHNGITGIVGPNGSGKSNVADAVRWVLGEQRSRQLRGGTMQDVIFAGTELRKPQGFAYVAITLDNADHKLPIEYDEVTVSRRLYRSGESEYKINGTSCRLKDINELFYDTGIGKEGYSIIGQGQIDQILRGRPEERRELFDEAAGIVKFKRRKAIAQKKLEDEKQNLIRVTDILSELEKQVGPLERQSEEAKEYLRLREELRCLDANLFLAESEELKRQIREVEQKEMILTGDQESVRAESETLKSEYELLGTELDALDAAIAADREACSREDLERQEKTGRIGVLREQIRTEQMNEEHIRSRMASIDGEMHQKEEEQAEYESEKQALNASVQMIEAKQQEAEAAVRSMDEAVSRTETLIETAKAEIMDALNQKAELAARRQRYETMLEQADVRRAEVTQKLLKFKSDESVQEEQKKEEEAKLGKVRECLEAFSAQEKELQEQTRTEEEQERRLNQKLSSLQQDYHTNRTKLESMRNLAERYEGYGGSIRRVMEVRNCVPGIHGVVADLISTTKKYETAIETALGGSIQNIVTDSEETAKRLIEHLKKNRYGRATFLPLTSMERRQSFGQPGALKEMGVLGLASELVSADEKYSGLVSYLLGRVVVVDQIDHAIALAKKYRHSLRIVTLDGELLSPGGSMTGGAFKNSSNLLGRRREIEELEAACKKALEQVEAVQKELAETGRRLTEAKRTLASVQERRQQMQIQQNTLELTICQLEARRQEIADSSQDLSSENQELELQVGDLRGALRELQTEETKLETLSNEKNQYVEEQQTGLETAKKQRGEAAAALSEIQLGHSQAEQKGAFIEENLRRVLQEQERLRAEKEKLSGGHADSSETIAAREREIAALEAEIQASGDKRTQMELVIQNKQREKEEKAGRQKTFFDKKEELNERLQLLDRENFRLQNQRERLNERLESQVDYMWSEYELTYSRAEELRKEELTSIPEMKRSINGKKMEIRALGNVNVNAIEDYKEISGRYEFMKNQHEDLVAAQAALEKIIEELDEGMRRQFREKFGEIRREFDKVFKELFGGGTGTLELSQEEDILEAGIQIISQPPGKKLQNMMQLSGGEKALTAIALLFAIQNLKPSPFCLLDEIEAALDDSNVDRFAGYLHKLTRYTQFIVITHRRGTMVSADRLYGITMQEKGVSTLVSVSLIEAQMEREEEKQNYNCKKELRNRKGGAAMGEKKKGFFSRLVEGLTKTRDSIVSGIDSVFSGFSAIDDDFYEEIEETLIMGDLGIQTTMAIVEDLRKKVKENHIKDPAECKDLLIASIKEQMDLGENAYEFENRKSVVLVIGVNGVGKTTSVGKLAGQLKDQGKKVILAAADTFRAAAIEQLTEWAGRAGVDLIAQQEGSDPAAVIYDAIAAAKSRNADVLICDTAGRLHNKKNLMEELKKINRIIDKEYPDAYRETLVVLDGTTGQNALAQAKQFMEVADITGIILTKLDGTAKGGIAVAIQSELGIPVKYVGIGEKIDDLQKFDANDFVNALFKRNEALTENE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias459-476Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QUDH01000002
EMBL· GenBank· DDBJ
RHO68959.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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