A0A3Q9UJF7 · A0A3Q9UJF7_9ACTN

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site255(6S)-NADPHX (UniProtKB | ChEBI)
Binding site305(6S)-NADPHX (UniProtKB | ChEBI)
Binding site349(6S)-NADPHX (UniProtKB | ChEBI)
Binding site415AMP (UniProtKB | ChEBI)
Binding site416(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase

Gene names

    • Name
      nnrD
    • ORF names
      C0Z10_03360

Organism names

  • Taxonomic identifier
  • Strain
    • JS280
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Propionibacteriaceae > Acidipropionibacterium

Accessions

  • Primary accession
    A0A3Q9UJF7

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-216YjeF N-terminal
Domain220-470YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    490
  • Mass (Da)
    50,020
  • Last updated
    2019-04-10 v1
  • Checksum
    A11346860CF51A17
MTTVCTAEQMRTAERAFFDAHPGADLMAVAAHAAATTAVTMLLGDEPLEESAEWIAQQRVLVMAGTGNNGADGLFAAAELCRDGWVVDVCPVLGSLHEAGAAAAQEAGCGEVSPVDALDRHYDLAIDAVLGIGGRPSIPDCLARLDEALAGADTPVLAVDLPSGLSADSGEVVRCVHARTTVTFASRKWCHLARPAAACCGRVILADIGVTVPDADQVASVTDLADLWPVPGPASDKYSRGVVGCDTGSSQYPGAGVLGVLGALRSGAGMVRCVGPDAVRQHVMDRTPSVVCADGRVQAWVVGSGWGDDAGNAARLDRRLADGVPVVVDADALAVLPRRIPEGCLLTPHAGELARMLGIDRAEVEADRRGSCLAGARMFGATVLLKGSIQWVATPDQQISAALPGPAWTAQAGSGDTLAGVCGTLLAAGLSARDAGLAGAGLQALAAICNPGPWSPDQLADRFPEVIARLVAPGPAGAAEREFVEREFSA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP025570
EMBL· GenBank· DDBJ
AZZ38947.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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