A0A3Q9U4Z5 · PVHC_TALVA

Function

function

Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of varicidin A, an antifungal natural product containing a cis-octahydrodecalin core (PubMed:30609896).
The PKS module of pvhA together with the enoylreductase pvhC catalyze the formation of the polyketide unit which is then conjugated to L-isoleucine by the condensation domain of the NRPS module (PubMed:30609896).
Activity of the Dieckmann cyclase domain (RED) of pvhA results in release of an acyclic tetramate (PubMed:30609896).
The cytochrome P450 monooxygenase pvhE then catalyzes the oxidation of the C21 methyl group to a to carboxylate group (PubMed:30609896).
The methyltransferase pvhD then further methylates the pvhE product (PubMed:30609896).
The Diels-Alderase pvhB is able to catalyze Diels-Alder cycloaddition using both pvhE and pvhD products as substrates to form the decalin ring, yielding varicidin B and A, respectively (PubMed:30609896).

Pathway

Secondary metabolite biosynthesis.

Features

Showing features for binding site.

135850100150200250300350
TypeIDPosition(s)Description
Binding site48-51NADP+ (UniProtKB | ChEBI)
Binding site134-141substrate
Binding site169-172NADP+ (UniProtKB | ChEBI)
Binding site192-195NADP+ (UniProtKB | ChEBI)
Binding site210NADP+ (UniProtKB | ChEBI)
Binding site257-258NADP+ (UniProtKB | ChEBI)
Binding site278-282substrate
Binding site347-348NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionnucleotide binding
Molecular Functionoxidoreductase activity, acting on NAD(P)H

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Trans-enoyl reductase pvhC
  • EC number
  • Short names
    ER pvhC
  • Alternative names
    • Varicidin biosynthesis cluster protein C

Gene names

    • Name
      pvhC

Organism names

Accessions

  • Primary accession
    A0A3Q9U4Z5

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004533371-358Trans-enoyl reductase pvhC

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    358
  • Mass (Da)
    38,438
  • Last updated
    2019-04-10 v1
  • Checksum
    915F332F1B336453
MPSRTQNIQSAWIGTTDGGSRLAHDAPIPAIARERVLIKTKAVSVSPVDSKLVGPYVTPNAVAGFDFSGIVEELGPEATKCGLKVGDRVCSAVVGMNPADPTIGAFAEYTAAVEWILLKLPPSITFEQGATLGISFLTSGLALFRSLGIPGRPLEPAPKPLCILVYGGSSSCGTASLQLLREAGHIPITTCSPHNFELVKSYGAVDAFDYNDPDTMDKIKKYTKNGLRYALDCISTTSSMQFCYKVIGRAGGKYTSLEPFSAAVAQTRKVVSPDWVMGPSLLGQEVAWPEPHYRKQDDDLAQFGAEWTATLNQLLKKELIKPHPMQIRDGGLENIQQGLEDLRAKKVSGAKIVYPLGS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK376933
EMBL· GenBank· DDBJ
AZZ09612.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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