A0A3Q9FJI1 · A0A3Q9FJI1_9BACT

  • Protein
    GDP-L-fucose synthase
  • Gene
    fcl
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Catalytic activity

Pathway

Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.

Features

Showing features for binding site, site, active site.

131320406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site11-17NADP+ (UniProtKB | ChEBI)
Binding site106-109NADP+ (UniProtKB | ChEBI)
Site108Important for catalytic activity
Site110Important for catalytic activity
Active site137Proton donor/acceptor
Binding site141NADP+ (UniProtKB | ChEBI)
Binding site164-167NADP+ (UniProtKB | ChEBI)
Binding site180NADP+ (UniProtKB | ChEBI)
Binding site188substrate
Binding site203substrate
Binding site210substrate
Binding site270substrate

GO annotations

AspectTerm
Molecular FunctionGDP-L-fucose synthase activity
Molecular Functionisomerase activity
Molecular FunctionNADP+ binding
Biological Process'de novo' GDP-L-fucose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GDP-L-fucose synthase
  • EC number
  • Alternative names
    • GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase

Gene names

    • Name
      fcl
    • ORF names
      EI427_04635

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • L12M1
  • Taxonomic lineage
    Bacteria > Bacteroidota > Cytophagia > Cytophagales > Flammeovirgaceae > Flammeovirga

Accessions

  • Primary accession
    A0A3Q9FJI1

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-238NAD-dependent epimerase/dehydratase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    313
  • Mass (Da)
    35,181
  • Last updated
    2019-04-10 v1
  • Checksum
    EEDAD251397C9926
MEKTSKIYIAGHRGMVGSAIHRKLVAEGYNNIVVRTSADLDLKDQVAVTAFFEEEKPEYVFLAAAKVGGIQANNIYRAQFLYENLMIQNNVIHQSYVHGVKKLMFLGSSCIYPKMAPQPLKEDYLLTGILESTNEPYAIAKISGIKMCEAYRAQYGCNFISAMPTNLYGYNDNYHPQNSHVLPALLRKFHEAKESNAPTVEVWGSGSPLREFMFVDDLAAACFFLMQNYDGEQFVNVGTGVDLSIKELAETIKEVVGFEGDLVWDTSKPDGTPRKLMDVSKLNNLGFKHKVELKEGIELTYKDFVAKNEFAER

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP034562
EMBL· GenBank· DDBJ
AZQ61539.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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