A0A3Q7PUM9 · A0A3Q7PUM9_CALUR
- ProteinMultidrug and toxin extrusion protein
- GeneLOC112817054
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids810 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- H+(in) + thiamine(out) = H+(out) + thiamine(in)
- agmatine(in) + H+(out) = agmatine(out) + H+(in)This reaction proceeds in the forward and the backward directions.
- creatinine(in) + H+(out) = creatinine(out) + H+(in)
- estrone 3-sulfate(in) + H+(out) = estrone 3-sulfate(out) + H+(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | xenobiotic transmembrane transporter activity | |
Biological Process | organic cation transport | |
Biological Process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Names & Taxonomy
Protein names
- Recommended nameMultidrug and toxin extrusion protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Pinnipedia > Otariidae > Callorhinus
Accessions
- Primary accessionA0A3Q7PUM9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 277-302 | Helical | ||||
Sequence: ALLVLAGPAFLAQLMMFLISFVSSVF | ||||||
Transmembrane | 314-333 | Helical | ||||
Sequence: VTLAIAVINVTGVSVGFGLS | ||||||
Transmembrane | 354-374 | Helical | ||||
Sequence: VILQKGTLVLLLCCLPCWALF | ||||||
Transmembrane | 394-413 | Helical | ||||
Sequence: TQDYVMVFIPALPATFLYTL | ||||||
Transmembrane | 425-445 | Helical | ||||
Sequence: LPQILTGVVANLVNALIHYAF | ||||||
Transmembrane | 451-476 | Helical | ||||
Sequence: LGVIGSALANMISQFTLALLLFFYIL | ||||||
Transmembrane | 496-517 | Helical | ||||
Sequence: WASFLSLAIPGMLMLCVEWWAY | ||||||
Transmembrane | 537-558 | Helical | ||||
Sequence: VVYELTVILYMIPSGFSVAASV | ||||||
Transmembrane | 578-605 | Helical | ||||
Sequence: VALLVTGVFAVAFCVLLLSCKDVVGYIF | ||||||
Transmembrane | 611-628 | Helical | ||||
Sequence: IIALVAQVIPISAIAHLF | ||||||
Transmembrane | 649-670 | Helical | ||||
Sequence: ALVNTIGYYMIGLPVGISLMFT | ||||||
Transmembrane | 676-698 | Helical | ||||
Sequence: VGLWSGIIICVITQSLCFLSFIA | ||||||
Transmembrane | 787-806 | Helical | ||||
Sequence: LLFLGLISVLLIGILVRVYV |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-48 | Disordered | ||||
Sequence: MRASAQPALLAGRPGRATTRDSSSPDVSQSETSVGRRSRAGASPGVRG | ||||||
Compositional bias | 17-37 | Polar residues | ||||
Sequence: ATTRDSSSPDVSQSETSVGRR | ||||||
Region | 83-110 | Disordered | ||||
Sequence: GRPRRGRDARDAPKVAAGPGAAGGLAMR | ||||||
Region | 140-186 | Disordered | ||||
Sequence: GRMETADETGPGGQGATPERPGGPGAIPKRPGATLKRPGATLKRPVA | ||||||
Region | 232-267 | Disordered | ||||
Sequence: RPVVTPERPVVTPERPGATPERPGATPERPGPSGSL |
Sequence similarities
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length810
- Mass (Da)86,212
- Last updated2019-04-10 v1
- Checksum2F7CB4BA590BCAFC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 17-37 | Polar residues | ||||
Sequence: ATTRDSSSPDVSQSETSVGRR |
Keywords
- Technical term