Staphylococcus aureus alpha-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry.Yang F., Suo M., Weli H., Wong M., Junidi A., Cummings C., Johnson R., Mallory K., Liu A.Y.[...], Clemens R.A.View abstractCategoriesNames, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCCell Rep 42:113394-113394 (2023)Mapped to27
COMMD10 Is Essential for Neural Plate Development during Embryogenesis.Phan K.P., Pelargos P., Tsytsykova A.V., Tsitsikov E.N., Wiley G., Li C., Bebak M., Dunn I.F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCJ Dev Biol 11:13-13 (2023)Mapped to8
Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells.Wang C., Nistala R., Cao M., Pan Y., Behrens M., Doll D., Hammer R.D., Nistala P., Chang H.M.[...], Kang X.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCCell Rep 42:112105-112105 (2023)Mapped to19
FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation.Li Y., Yang W., Patel R.M., Casey E.B., Denby E., Mendoza-Castrejon J., Rodriguez-Lopez P., Magee J.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCBlood 141:1442-1456 (2023)Mapped to36
TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells.Rodrigues M., Petrova T., Tibbs B., Arthur J.S.C., Cohen P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCBiochem J 479:1891-1907 (2022)Mapped to19
The X-Linked Helicase DDX3X Is Required for Lymphoid Differentiation and MYC-Driven Lymphomagenesis.Lacroix M., Beauchemin H., Fraszczak J., Ross J., Shooshtarizadeh P., Chen R., Moroy T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCCancer Res 82:3172-3186 (2022)Mapped to34
Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of beta-catenin degradation.Jimbo K., Nakajima-Takagi Y., Ito T., Koide S., Nannya Y., Iwama A., Tojo A., Konuma T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCLeukemia 36:1550-1562 (2022)Mapped to14
Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms.Saleiro D., Wen J.Q., Kosciuczuk E.M., Eckerdt F., Beauchamp E.M., Oku C.V., Blyth G.T., Fischietti M., Ilut L.[...], Platanias L.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCNat Commun 13:1750-1750 (2022)Mapped to19
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.Muto T., Guillamot M., Yeung J., Fang J., Bennett J., Nadorp B., Lasry A., Redondo L.Z., Choi K.[...], Starczynowski D.T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCCell Stem Cell 29:298-314.e9 (2022)Mapped to21
Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation.Houde N., Beuret L., Bonaud A., Fortier-Beaulieu S.P., Truchon-Landry K., Aoidi R., Pic E., Alouche N., Rondeau V.[...], Charron J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCCell Rep 38:110223-110223 (2022)Mapped to26
Association of clonal hematopoiesis with chronic obstructive pulmonary disease.COPDGene Study Investigators, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine ConsortiumMiller P.G., Qiao D., Rojas-Quintero J., Honigberg M.C., Sperling A.S., Gibson C.J., Bick A.G., Niroula A., McConkey M.E.[...], Ebert B.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCBlood 139:357-368 (2022)Mapped to14
U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice.Wadugu B.A., Nonavinkere Srivatsan S., Heard A., Alberti M.O., Ndonwi M., Liu J., Grieb S., Bradley J., Shao J.[...], Walter M.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCJ Clin Invest 131:e141401-e141401 (2021)Mapped to21
The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice.Maes B., Smole U., Vanderkerken M., Deswarte K., Van Moorleghem J., Vergote K., Vanheerswynghels M., De Wolf C., De Prijck S.[...], Hammad H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCJ Allergy Clin Immunol 149:1413-1427.e2 (2022)Mapped to26
Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing.Chua K., Lee V.K., Chan C., Yew A., Yeo E., Virshup D.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCFront Endocrinol (Lausanne) 12:667480-667480 (2021)Mapped to12
Blockade of IL-22 signaling reverses erythroid dysfunction in stress- induced anemias.Raundhal M., Ghosh S., Myers S.A., Cuoco M.S., Singer M., Carr S.A., Waikar S.S., Bonventre J.V., Ritz J.[...], Glimcher L.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCNat Immunol 22:520-529 (2021)Mapped to50
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNgamma signaling.Hormaechea-Agulla D., Matatall K.A., Le D.T., Kain B., Long X., Kus P., Jaksik R., Challen G.A., Kimmel M., King K.Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCCell Stem Cell 28:1428-1442.e6 (2021)Mapped to13
Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid.Walker F.C., Hassan E., Peterson S.T., Rodgers R., Schriefer L.A., Thompson C.E., Li Y., Kalugotla G., Blum-Johnston C.[...], Baldridge M.T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCPLoS Pathog 17:e1009402-e1009402 (2021)Mapped to35
Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy.Chen R., Okeyo-Owuor T., Patel R.M., Casey E.B., Cluster A.S., Yang W., Magee J.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCCell Rep 34:108751-108751 (2021)Mapped to29
Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance.Tsyklauri O., Niederlova V., Forsythe E., Prasai A., Drobek A., Kasparek P., Sparks K., Trachtulec Z., Prochazka J.[...], Stepanek O.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCEMBO Rep 22:e50785-e50785 (2021)Mapped to12
Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant.Robledo R.F., Ciciotte S.L., Graber J.H., Zhao Y., Lambert A.J., Gwynn B., Maki N.J., Brindley E.C., Hartman E.[...], Peters L.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCPLoS Genet 16:e1008857-e1008857 (2020)Mapped to21
ZBTB38 is dispensable for antibody responses.Wong R., Bhattacharya D.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCPLoS One 15:e0235183-e0235183 (2020)Mapped to14
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition.Inclan-Rico J.M., Ponessa J.J., Valero-Pacheco N., Hernandez C.M., Sy C.B., Lemenze A.D., Beaulieu A.M., Siracusa M.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCNat Immunol 21:1181-1193 (2020)Mapped to24
Novel Mutations and Decreased Expression of the Epigenetic Regulator <i>TET2</i> in Pulmonary Arterial Hypertension.Potus F., Pauciulo M.W., Cook E.K., Zhu N., Hsieh A., Welch C.L., Shen Y., Tian L., Lima P.[...], Archer S.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCCirculation 141:1986-2000 (2020)Mapped to17
Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development.Chu S.H., Chabon J.R., Matovina C.N., Minehart J.C., Chen B.R., Zhang J., Kumar V., Xiong Y., Callen E.[...], Armstrong S.A.View abstractCategoryPhenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCiScience 23:100941-100941 (2020)Mapped to24
Efficient genome-wide first-generation phenotypic screening system in mice using the <i>piggyBac</i> transposon.Chang H., Pan Y., Landrette S., Ding S., Yang D., Liu L., Tian L., Chai H., Li P.[...], Xu T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1916706PubMedEurope PMCProc Natl Acad Sci U S A 116:18507-18516 (2019)Mapped to12