A0A3Q2I5Q7 · A0A3Q2I5Q7_HORSE

  • Protein
    Receptor protein-tyrosine kinase
  • Gene
    EGFR
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

Features

Showing features for binding site, active site.

111931002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site718-726ATP (UniProtKB | ChEBI)
Binding site745ATP (UniProtKB | ChEBI)
Active site837Proton acceptor

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentcell junction
Cellular Componentcell surface
Cellular Componentearly endosome membrane
Cellular Componentendocytic vesicle
Cellular Componentmembrane raft
Cellular Componentmultivesicular body, internal vesicle lumen
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular Componentreceptor complex
Cellular Componentruffle membrane
Molecular Functionactin filament binding
Molecular FunctionATP binding
Molecular Functionchromatin binding
Molecular Functionepidermal growth factor binding
Molecular Functionepidermal growth factor receptor activity
Molecular Functionidentical protein binding
Molecular Functionkinase binding
Molecular Functionprotein phosphatase binding
Molecular Functiontransmembrane receptor protein tyrosine kinase activator activity
Molecular Functionubiquitin protein ligase binding
Biological Processcell morphogenesis
Biological Processcell-cell adhesion
Biological Processcellular response to amino acid stimulus
Biological Processcellular response to estradiol stimulus
Biological Processcellular response to growth factor stimulus
Biological Processcerebral cortex cell migration
Biological Processdigestive tract morphogenesis
Biological Processembryonic placenta development
Biological Processepithelial cell proliferation
Biological ProcessERBB2-EGFR signaling pathway
Biological Processeyelid development in camera-type eye
Biological Processhair follicle development
Biological Processmorphogenesis of an epithelial fold
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of cardiocyte differentiation
Biological Processnegative regulation of epidermal growth factor receptor signaling pathway
Biological Processnegative regulation of protein catabolic process
Biological Processpeptidyl-tyrosine phosphorylation
Biological Processpositive regulation of canonical Wnt signaling pathway
Biological Processpositive regulation of cell growth
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Processpositive regulation of DNA repair
Biological Processpositive regulation of DNA replication
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of fibroblast proliferation
Biological Processpositive regulation of G1/S transition of mitotic cell cycle
Biological Processpositive regulation of miRNA transcription
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of protein kinase C activity
Biological Processpositive regulation of protein localization to plasma membrane
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of peptidyl-tyrosine phosphorylation
Biological Processresponse to UV-A
Biological Processsalivary gland morphogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Receptor protein-tyrosine kinase
  • EC number

Gene names

    • Name
      EGFR

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A3Q2I5Q7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane646-668Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_504045909725-1193Receptor protein-tyrosine kinase

Keywords

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain712-979Protein kinase

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,193
  • Mass (Da)
    132,978
  • Last updated
    2023-09-13 v2
  • Checksum
    2C27DF50A704B5AB
MRHSGTVGAALLVLLAAYFQASPALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYMQKNYDLSFLKTIQEVAGYVLIALNTVEKIPLENLQIIRGNVLYENTHALSVLSNYGANKVGLRELPMRNLQEILQGAVRFSNNPILCNMETIQWRDIVNSDFLSNMSVDFQNQLGSCQKCDPACPNGSCWGVGKENCQKLTKTICAQQCSGRCRGRSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPDGKYSFGATCVKKCPRNYVVTDHGSCVRACSSDSYEVEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTRTPPLDPKELDILQTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNRNLCYANTIKWKKLFGTSSQKTKIINNRSEKDCKTVGHVCNLLCSSEGCWGPEPRDCVSCQNVSRGKECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIKCAHYIDGPHCVKTCPSGIMGENNTLVWKFADANHVCHLCHPNCTYGCAGPGLEGCARNGPKIPSIATGIVGGLLLVVVVALGIGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRTLMDEEDMEDVVDADEYLIPQQGFFHSPSTSRTPLISSLQSCPLKEDSFLQRYSSDPTGTVTEDNIDDTFLPAPEYVNQSVPKRPAGSVQNPVYHNQPLNPAPGRDPHYQNPHSNAMDNPEYLNTTHPDCVNSVLDGTALWAQKGNHQISLDNPDYQQDFFPKEAKSNGIFKGPAAENAEYLRVAPPSSEFIGA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q2L870A0A3Q2L870_HORSEEGFR1156

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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