A0A3Q2HHN9 · A0A3Q2HHN9_HORSE

  • Protein
    Adenylate cyclase type 6
  • Gene
    ADCY6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site381Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site381Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site382Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site425Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site425Mg2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate cyclase type 6
  • EC number

Gene names

    • Name
      ADCY6

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A3Q2HHN9

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane150-170Helical
Transmembrane176-196Helical
Transmembrane208-228Helical
Transmembrane234-251Helical
Transmembrane258-276Helical
Transmembrane288-308Helical
Transmembrane666-687Helical
Transmembrane693-716Helical
Transmembrane737-756Helical
Transmembrane812-830Helical
Transmembrane837-859Helical
Transmembrane890-908Helical

Keywords

  • Cellular component

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain376-503Guanylate cyclase
Domain976-1115Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,153
  • Mass (Da)
    129,127
  • Last updated
    2023-09-13 v2
  • MD5 Checksum
    35AF8F8358E9F4B60144E3F799EAB3D9
MSWFSGLLVPKVDERKTAWGERNGQKRQRRGTRTSGFCAPRYISCLQDAQPPSPTPAAPAQCRWQDEAFIRRGGPGKGKELGLRAVALAFEDTEAAAVARAAEVAPDVAPRSRRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPAPPQPAYVALLACAAALFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPHSPSVGLWCPVFFVYITYTLLPIRMRAAVFSGLGLSTLHLILAWQLNRGDAFLWKQLGANMMLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQRLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSVEGLMPRWVPDRAFSRAKDSKAFRQMGIDDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLTCAVYSCGSLFPKALQRLSRSIVRSRAHSTVVGIFSVLLVFTSAIANMFTCNHTPIRTCAARMLNLTPADITACHLQQLNYSLGLDAPLCEDTAPTCSFPEYLVGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQLFAEAWCLAQTVCLGGSSHINQMIHQALH

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A9L0T0S7A0A9L0T0S7_HORSEADCY61166
A0A3Q2H223A0A3Q2H223_HORSEADCY61132
F7BRW3F7BRW3_HORSEADCY61113

Keywords

Genome annotation databases

Similar Proteins

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