A0A3Q2HHN9 · A0A3Q2HHN9_HORSE
- ProteinAdenylate cyclase type 6
- GeneADCY6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1153 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 381 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 381 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 382 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 425 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 425 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate cyclase type 6
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus
Accessions
- Primary accessionA0A3Q2HHN9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 150-170 | Helical | |||
Transmembrane | 176-196 | Helical | |||
Transmembrane | 208-228 | Helical | |||
Transmembrane | 234-251 | Helical | |||
Transmembrane | 258-276 | Helical | |||
Transmembrane | 288-308 | Helical | |||
Transmembrane | 666-687 | Helical | |||
Transmembrane | 693-716 | Helical | |||
Transmembrane | 737-756 | Helical | |||
Transmembrane | 812-830 | Helical | |||
Transmembrane | 837-859 | Helical | |||
Transmembrane | 890-908 | Helical | |||
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 376-503 | Guanylate cyclase | |||
Domain | 976-1115 | Guanylate cyclase | |||
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,153
- Mass (Da)129,127
- Last updated2023-09-13 v2
- MD5 Checksum35AF8F8358E9F4B60144E3F799EAB3D9
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A9L0T0S7 | A0A9L0T0S7_HORSE | ADCY6 | 1166 | ||
A0A3Q2H223 | A0A3Q2H223_HORSE | ADCY6 | 1132 | ||
F7BRW3 | F7BRW3_HORSE | ADCY6 | 1113 |
Keywords
- Technical term