A0A3Q2GZW1 · A0A3Q2GZW1_HORSE

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentearly endosome
Cellular Componentplasma membrane
Molecular Functiondouble-stranded RNA binding
Molecular Functionidentical protein binding
Molecular Functionpattern recognition receptor activity
Molecular Functiontransmembrane signaling receptor activity
Molecular Functionubiquitin-like protein ligase binding
Biological Processcellular response to exogenous dsRNA
Biological Processcellular response to mechanical stimulus
Biological Processcellular response to virus
Biological Processdefense response to virus
Biological Processextrinsic apoptotic signaling pathway
Biological ProcessI-kappaB phosphorylation
Biological Processinflammatory response to wounding
Biological Processinnate immune response
Biological ProcessJNK cascade
Biological Processnecroptotic signaling pathway
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of chemokine production
Biological Processpositive regulation of cytokine production involved in inflammatory response
Biological Processpositive regulation of interferon-alpha production
Biological Processpositive regulation of interferon-beta production
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of interleukin-8 production
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of macrophage cytokine production
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of tumor necrosis factor production
Biological Processpositive regulation of type II interferon production
Biological Processpositive regulation of type III interferon production
Biological Processregulation of dendritic cell cytokine production
Biological Processtoll-like receptor 3 signaling pathway
Biological Processtoll-like receptor signaling pathway
Biological Processtype III interferon production

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Toll like receptor 3

Gene names

    • Name
      TLR3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A3Q2GZW1

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane738-759Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_504041144223-938

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain788-931TIR

Sequence similarities

Belongs to the Toll-like receptor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    938
  • Mass (Da)
    108,063
  • Last updated
    2023-09-13 v3
  • Checksum
    3407B9174A8C5C9E
MSQSLPYHVYSFLRLLPFWVLCASCNKCAVRHEVADCSHLKLTQIPDDLPANITVLNLTHNQFRRLPPDNFTRYSQLTILDGGFNCISKLEPELCQKLPLLEILDLQHNELSQFSDKTFMFCMNLTELHLRSNSIQKIQNNPFKNLKNLIKLDLSHNGLSSTKLGTQLQLENLQELLLSNNKIQALRRDELDFLGNSSLKKLELSSNQIKESPYWRNLIKYINNEGENKNHPKVHNPETTSVSIWFSPGCFQAIGKLFGLSLNSVQLGPSLTEKLCLELSNTSIQNLSLSNTQLYRTSNTTFFGLKQTNLTMLDLSHNNLNVIGNDSFAWLPHLEYFFLEYNNIEHLYVHSFYGLFNVRYLNLRRSFTKQSISLASLPKIDDFSFQWLKCLEYLNMEDNNFPGIKSNMFTGLVKLKHLSLSNSFSSLRTLTNETFLSLAHSPLLTLNLTKNKISKLESGAFSWLGHLKILDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTSNSFALVPSLQRLMLRRVALKNVDSFPPPFRPLHNLTILDLSNNNIANINDELLEGLEKLEVLDLQHNNLARLWKHANPGGPVHFLKGLSHLHVLNLESNGFDEIPAEAFKNLFELKSINLGLNNLNILPPSVFDDQVSLKSLSLQKNLITSVEKNVFGPALKNLSSLDMSFNPFDCTCESIAWFVNWINGTHTNISELSSHYLCNTPPQYHGFPVMLFDTSSCKDSAPFELLFMINTSFLLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDSQPEQFEYAAYIIHAYKDRDWVWEHFSPMEEQDQTLKFCLEERDFQAGVLELEAIINSIKRSRKIIFIITQHLLKDPLCKRFKVHHAVQQAIEQNLDSIILIFLEEIPDYKLNHALCLRRGMFKSRCILNWPVQKERINAFHHKLQVALGSRNSAH

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F5PQZ3A0A5F5PQZ3_HORSETLR3908
F7CCY6F7CCY6_HORSETLR3933
A0A3Q2HFC7A0A3Q2HFC7_HORSETLR3920

Keywords

Genome annotation databases

Similar Proteins

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