A0A3Q2GXY4 · A0A3Q2GXY4_HORSE

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell-cell contact zone
Cellular Componentcentrosome
Cellular Componentcilium
Cellular Componentcytosol
Cellular ComponentFNIP-folliculin RagC/D GAP
Cellular Componentlysosomal membrane
Cellular Componentmidbody
Cellular Componentmitotic spindle
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionenzyme binding
Molecular Functionenzyme inhibitor activity
Molecular FunctionGTPase activator activity
Molecular Functionprotein-containing complex binding
Biological Processcell proliferation involved in kidney development
Biological Processcell-cell junction assembly
Biological Processcellular response to amino acid starvation
Biological Processenergy homeostasis
Biological Processepithelial cell proliferation
Biological ProcessERK1 and ERK2 cascade
Biological Processhemopoiesis
Biological Processin utero embryonic development
Biological Processintrinsic apoptotic signaling pathway
Biological Processlysosome localization
Biological Processnegative regulation of brown fat cell differentiation
Biological Processnegative regulation of cell proliferation involved in kidney development
Biological Processnegative regulation of cold-induced thermogenesis
Biological Processnegative regulation of epithelial cell proliferation
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of glycolytic process
Biological Processnegative regulation of lysosome organization
Biological Processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processnegative regulation of post-translational protein modification
Biological Processnegative regulation of Rho protein signal transduction
Biological Processnegative regulation of TOR signaling
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processphosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of autophagy
Biological Processpositive regulation of intrinsic apoptotic signaling pathway
Biological Processpositive regulation of TORC1 signaling
Biological Processpositive regulation of transforming growth factor beta receptor signaling pathway
Biological Processregulation of pro-B cell differentiation
Biological Processregulation of Ras protein signal transduction
Biological ProcessTOR signaling
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Folliculin

Gene names

    • Name
      FLCN

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A3Q2GXY4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-63Disordered
Region111-162Disordered
Domain166-637UDENN FLCN/SMCR8-type
Region374-412Disordered
Compositional bias383-406Basic and acidic residues

Sequence similarities

Belongs to the folliculin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    658
  • Mass (Da)
    72,813
  • Last updated
    2023-09-13 v2
  • Checksum
    651484D630BDCB9E
MLFKLKHPPLEMVSSSGPRRGGRNHSGVVGGGAGEGRRGSGRARGRGAPAGRRWYGPPGHALGPARARRRARALCRPQSTMNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGTGDSPGQGEQAEEEEGGIQMSSRIRAHSPAEGASTESSSPGPKKSDMCEGCRSLAAGHPGYISHDKETSIKYVSHQHPNHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINSWPFLLGKIRGIIDELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHTSFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEKTPVLPEGAEGRELTKRPTDSSLLSDCGNWQPRKLSVFRSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDADLVQSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPQVQIPSHVLSSEFAVIVEVHTATRSSLHPVGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKMEAALTNQNLSVDVVDQCLVCLKEEWMNKVKVLFKFTKVDSRPKEDTQKLLSILGASEEDNVKLLKFWMTGLSKTYKSHLMSTVRSPSASEPRN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q2LPC0A0A3Q2LPC0_HORSEFLCN578

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias383-406Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp