A0A3Q2GXQ8 · A0A3Q2GXQ8_HORSE
- Proteinmitogen-activated protein kinase kinase kinase
- GeneMAP3K10
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids904 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 125 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemitogen-activated protein kinase kinase kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus
Accessions
- Primary accessionA0A3Q2GXQ8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 16-81 | SH3 | |||
Domain | 98-366 | Protein kinase | |||
Coiled coil | 391-444 | ||||
Region | 490-769 | Disordered | |||
Compositional bias | 525-539 | Polar residues | |||
Compositional bias | 617-633 | Basic and acidic residues | |||
Region | 785-904 | Disordered | |||
Compositional bias | 882-896 | Polar residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length904
- Mass (Da)98,645
- Last updated2023-09-13 v2
- MD5 ChecksumF6336E68835E33740694B9E28A5F0085
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A9L0TE25 | A0A9L0TE25_HORSE | MAP3K10 | 931 | ||
A0A3Q2IAK9 | A0A3Q2IAK9_HORSE | MAP3K10 | 944 | ||
A0A9L0RDJ1 | A0A9L0RDJ1_HORSE | MAP3K10 | 322 | ||
A0A9L0TCQ1 | A0A9L0TCQ1_HORSE | MAP3K10 | 272 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 525-539 | Polar residues | |||
Compositional bias | 617-633 | Basic and acidic residues | |||
Compositional bias | 882-896 | Polar residues | |||
Keywords
- Technical term