A0A3Q2GWX9 · A0A3Q2GWX9_HORSE

  • Protein
    Delta(14)-sterol reductase LBR
  • Gene
    LBR
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear inner membrane
Cellular Componentnuclear lamina
Molecular Functionchromatin-protein adaptor activity
Molecular Functionchromo shadow domain binding
Molecular Functiondelta14-sterol reductase activity
Molecular FunctionDNA binding
Molecular FunctionNADPH binding
Biological Processcholesterol biosynthetic process
Biological Processneutrophil differentiation
Biological Processrandom inactivation of X chromosome

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase LBR
  • EC number
  • Short names
    C14SR
    ; Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Integral nuclear envelope inner membrane protein
    • Lamin-B receptor
    • Sterol C14-reductase

Gene names

    • Name
      LBR

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A3Q2GWX9

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Nucleus inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane214-234Helical
Transmembrane260-277Helical
Transmembrane298-317Helical
Transmembrane329-348Helical
Transmembrane450-472Helical
Transmembrane484-503Helical
Transmembrane523-545Helical
Transmembrane565-584Helical

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain4-62Tudor
Region52-106Disordered
Compositional bias59-75Polar residues
Compositional bias76-90Basic residues

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    617
  • Mass (Da)
    70,442
  • Last updated
    2019-04-10 v1
  • Checksum
    99B6F8ECA10CDCA8
MPSRKFADGELVRGRWPGSSLYFEVEILSHDSSSQLYTVKYKDGTELELKESDIKPLTSFRQRKSGSTSSSPSRRRGSRSRSRSRSPGRLPKGSRRSASASHQASVKEMRKEVLEVKLTPLVLKPFGNSISRYNGEPEHLERNDIPLKSTQEKFHLPQESSYVSTQYSLRPRREEIKLTEIDSKEEKIVTKAPPLARTGEVTGTRTKDWEFGGAPGAFLIMLGLPPFLFLLLLMCQQREPSLLNFPPPLPALRDLWETRVFGVYLLWFLLQTLFHLLPVGKVVEGMPLADGRRLKYRLNGFCAFILTSAVVGASVFWGVELYYVYRHFLQFALAATVFSVALSVYLSVRARKAPREELSPASSGNAIYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVVNLVMLLAEMKLQNRATPSLAMILVNSFQLLYVVDALWNEEAVLTTMDIIHDGFGFMLAFGDLVWVPFVYSLQAFYLVGHPNEVSWPVASLIIALKLCGYVIFRCANSQKNAFRKNPTDPKLAHLKTIHTSTGKSLLVSGWWGFVRHPNYLGDLVMALAWSLPCGFNHILPYFYVIYFTLLLIHREARDEHQCRKKYGLAWEKYCRRVPYRIFPHIY

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A9L0RLH2A0A9L0RLH2_HORSELBR590
F7AEU3F7AEU3_HORSELBR575

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias59-75Polar residues
Compositional bias76-90Basic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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