A0A3Q2GWX9 · A0A3Q2GWX9_HORSE
- ProteinDelta(14)-sterol reductase LBR
- GeneLBR
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids617 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Catalytic activity
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
- 4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H+ = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP+
- 5alpha-cholest-8,14-dien-3beta-ol + NADPH + H+ = 5alpha-cholest-8-en-3beta-ol + NADP+
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nuclear inner membrane | |
Cellular Component | nuclear lamina | |
Molecular Function | chromatin-protein adaptor activity | |
Molecular Function | chromo shadow domain binding | |
Molecular Function | delta14-sterol reductase activity | |
Molecular Function | DNA binding | |
Molecular Function | NADPH binding | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | neutrophil differentiation | |
Biological Process | random inactivation of X chromosome |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta(14)-sterol reductase LBR
- EC number
- Short namesC14SR ; Delta-14-SR
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus
Accessions
- Primary accessionA0A3Q2GWX9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Nucleus inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 214-234 | Helical | |||
Transmembrane | 260-277 | Helical | |||
Transmembrane | 298-317 | Helical | |||
Transmembrane | 329-348 | Helical | |||
Transmembrane | 450-472 | Helical | |||
Transmembrane | 484-503 | Helical | |||
Transmembrane | 523-545 | Helical | |||
Transmembrane | 565-584 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-62 | Tudor | |||
Region | 52-106 | Disordered | |||
Compositional bias | 59-75 | Polar residues | |||
Compositional bias | 76-90 | Basic residues | |||
Sequence similarities
Belongs to the ERG4/ERG24 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length617
- Mass (Da)70,442
- Last updated2019-04-10 v1
- Checksum99B6F8ECA10CDCA8
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A9L0RLH2 | A0A9L0RLH2_HORSE | LBR | 590 | ||
F7AEU3 | F7AEU3_HORSE | LBR | 575 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 59-75 | Polar residues | |||
Compositional bias | 76-90 | Basic residues | |||
Keywords
- Technical term