A0A3Q2GTP0 · A0A3Q2GTP0_HORSE

  • Protein
    PR domain zinc finger protein 1
  • Gene
    PRDM1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionhistone methyltransferase binding
Molecular Functionmetal ion binding
Molecular Functionmethyltransferase activity
Molecular Functionpromoter-specific chromatin binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processaorta development
Biological Processartery morphogenesis
Biological Processcell fate commitment
Biological Processcoronary vasculature development
Biological Processeye photoreceptor cell development
Biological Processgene expression
Biological Processgerm cell development
Biological Processheart valve development
Biological Processintestinal epithelial cell development
Biological Processkidney development
Biological Processmaternal placenta development
Biological Processmethylation
Biological Processmorphogenesis of a branching structure
Biological Processnegative regulation of gene expression
Biological Processpositive regulation of gene expression
Biological Processpost-embryonic development
Biological Processregulation of cell population proliferation
Biological Processregulation of extrathymic T cell differentiation
Biological Processregulation of natural killer cell differentiation
Biological Processregulation of NK T cell differentiation
Biological Processregulation of transcription by RNA polymerase II
Biological Processretinal bipolar neuron differentiation
Biological Processsebum secreting cell proliferation
Biological Processtrophoblast giant cell differentiation
Biological Processventricular septum development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    PR domain zinc finger protein 1
  • EC number

Gene names

    • Name
      PRDM1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A3Q2GTP0

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain81-198SET
Region261-286Disordered
Compositional bias322-359Polar residues
Region322-362Disordered
Domain572-599C2H2-type
Domain600-627C2H2-type
Domain628-655C2H2-type
Domain656-683C2H2-type
Region800-821Disordered

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    821
  • Mass (Da)
    91,398
  • Last updated
    2023-09-13 v2
  • Checksum
    69036499D258AEF5
MGIKGLPLLFQAAPKCSFSAVRFQELAEGTEGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKHSANSKEVIGVVSKEYIPKGTRFGPLIGEIYNNDTVPKNANRKYFWRIYSRGELHHFIDGFKEEKSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSHPKQQSTEKNELCPKSVPKREYSVKEILKLDSNPSKGKDFYRSNISPFTSEKDTDDFRKNGSPEVPFYPRVVYPIRAPLPEDFLKASLAYGMERPTYITHSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGTTVSPLAPGFQEPRDSYSYLNAPYGTEGLGSYPGYAPPPHLSSAFIPSYNAPYPKFLLPPYGMNCNGLSTVGNINSINNFGLFPRLYPVYSNFLGGGSLPHPMLNPASLPSSLPSEGARRLLQPEHPREVLVPAPHSAFSLTGAAASMKDKACSPTSGSPTAGTAATSEHVVQPKATSVAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCAHCHKSYIHLCSLKVHLKGNCPVAPAAGLPLEDLTRINEEIEKFDLSDNADRLEDMEDNIDVTSVVEKEILAVVRKEKEETGLKVSLQRNMGNGLLSGCGLYESSDPSLMKLPHSNPLPLGPVKVKQETVEPMDP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q2LBT5A0A3Q2LBT5_HORSEPRDM1781
A0A5F5PUT0A0A5F5PUT0_HORSEPRDM1690

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias322-359Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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