A0A3Q1NGD6 · A0A3Q1NGD6_BOVIN

  • Protein
    Histone deacetylase
  • Gene
    HDAC7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

Features

Showing features for binding site, active site, site.

1988100200300400500600700800900
Type
IDPosition(s)Description
Binding site569Zn2+ (UniProtKB | ChEBI)
Binding site571Zn2+ (UniProtKB | ChEBI)
Binding site577Zn2+ (UniProtKB | ChEBI)
Binding site654Zn2+ (UniProtKB | ChEBI)
Active site706
Site879Contributes to catalysis

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone deacetylase activity
Molecular Functionmetal ion binding
Biological Processnegative regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase
  • EC number

Gene names

    • Name
      HDAC7

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1NGD6

Proteomes

Organism-specific databases

Subcellular Location

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-18Polar residues
Region1-57Disordered
Compositional bias21-37Pro residues
Region185-265Disordered
Compositional bias235-259Polar residues
Region296-315Disordered
Region379-476Disordered
Compositional bias418-442Basic and acidic residues
Compositional bias455-469Basic and acidic residues
Region504-548Disordered
Compositional bias516-548Polar residues
Domain577-895Histone deacetylase

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    988
  • Mass (Da)
    106,721
  • Last updated
    2024-05-29 v2
  • Checksum
    813B816F40D7EF4C
MASAESAVDGTQVSPAAPCSSPPIIGWPRPRADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQHPQRLHHHLFLAGLQPQRSAEPMRLSMDTPMPELQMGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPSVPYRTLEPLETEGAARSMLSSFLPPVPSLPCDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPVLGSEALLGQRLRLQETSLAPFALLPTITLGLPAPARADGDRRTHATLGPRGPVLGNPHAHLFLPHGLEPEAGGPLPSRLQPILLLDPSVTHTPLLTVPGLGPLPFHFAQSLLTTERPSGSGLHRPLSRTRSEPLPPSATTPSLLGPLQPRLERLKPHVQLIKRSAKPSEKPRLRQIPSAEDLETDGGSVGPLRDDGLEHRESSHGQQEARGTVPLQQHQQVFLWEQQRLAGRLPRGATGDSVLLPLAPGSHRPLSRAQSSPAAPASLSTPEPASQARILPSSETPARTLPFTTGLVYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLLERGLRSQCESLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQGKASKILIVDWDVHHGNGTQQTFYQDPNVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPPPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLGNKVDPLSEEGWKQKPNLNAIRSLEAVIRVHSEYWGCMQRLASRPDSWVHRVPGADAEEVEAVTALASLSVGILAEERTSGQLVEEEEPMNL

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1N0A4A0A3Q1N0A4_BOVINHDAC71036
A0AAA9T6A2A0AAA9T6A2_BOVINHDAC7986
A0A3Q1MXW3A0A3Q1MXW3_BOVINHDAC7970
A0AAA9TGJ2A0AAA9TGJ2_BOVINHDAC7958
F1N616F1N616_BOVINHDAC7988
A0A3Q1MDL2A0A3Q1MDL2_BOVINHDAC7969
A0A3Q1MDB6A0A3Q1MDB6_BOVINHDAC7995
A0AAA9U2N9A0AAA9U2N9_BOVINHDAC7999
A0A3Q1MPP6A0A3Q1MPP6_BOVINHDAC7972

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-18Polar residues
Compositional bias21-37Pro residues
Compositional bias235-259Polar residues
Compositional bias418-442Basic and acidic residues
Compositional bias455-469Basic and acidic residues
Compositional bias516-548Polar residues

Keywords

Genome annotation databases

Similar Proteins

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