A0A3Q1NBU3 · A0A3Q1NBU3_BOVIN
- ProteinAlkylglycerone-phosphate synthase
- GeneAGPS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids713 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
Catalytic activity
- a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H+
Cofactor
Pathway
Glycerolipid metabolism; ether lipid biosynthesis.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 289-295 | FAD (UniProtKB | ChEBI) | ||||
Sequence: PIGGGTS | ||||||
Binding site | 358-364 | FAD (UniProtKB | ChEBI) | ||||
Sequence: DSLEFST | ||||||
Binding site | 371-374 | FAD (UniProtKB | ChEBI) | ||||
Sequence: TRAS | ||||||
Binding site | 423-429 | FAD (UniProtKB | ChEBI) | ||||
Sequence: EGTLGVI | ||||||
Site | 474 | Important for enzyme activity | ||||
Sequence: R | ||||||
Binding site | 570 | substrate | ||||
Sequence: R | ||||||
Active site | 633 | Proton donor/acceptor | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | alkylglycerone-phosphate synthase activity | |
Molecular Function | FAD binding | |
Biological Process | ether lipid biosynthetic process | |
Biological Process | lipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlkylglycerone-phosphate synthase
- EC number
- Short namesAlkyl-DHAP synthase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A3Q1NBU3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-109 | Disordered | ||||
Sequence: MVAPGAALSDLSPAPSGPGRWHKAEAMAEAAAAAGGTAAGAGSRSTTDRDRDRDPERDRAGRRLRVLSGHLLGRPQEALSTNDCKARRTAATGTAAPTATPAAQESGTI | ||||||
Compositional bias | 45-65 | Basic and acidic residues | ||||
Sequence: STTDRDRDRDPERDRAGRRLR | ||||||
Compositional bias | 82-107 | Polar residues | ||||
Sequence: NDCKARRTAATGTAAPTATPAAQESG | ||||||
Domain | 257-439 | FAD-binding PCMH-type | ||||
Sequence: FQRIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVVHIKMVTPRGIIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPI |
Sequence similarities
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length713
- Mass (Da)78,724
- Last updated2024-05-29 v2
- Checksum02F305FF74A4ABCF
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9SJX7 | A0AAA9SJX7_BOVIN | AGPS | 677 | ||
A0AAA9SPD5 | A0AAA9SPD5_BOVIN | AGPS | 665 | ||
E1BPV2 | E1BPV2_BOVIN | AGPS | 647 | ||
A0AAA9TIG7 | A0AAA9TIG7_BOVIN | AGPS | 189 | ||
A0AAA9TDZ7 | A0AAA9TDZ7_BOVIN | AGPS | 684 | ||
A0AAA9TCF5 | A0AAA9TCF5_BOVIN | AGPS | 676 | ||
A0AAA9TPF8 | A0AAA9TPF8_BOVIN | AGPS | 654 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 45-65 | Basic and acidic residues | ||||
Sequence: STTDRDRDRDPERDRAGRRLR | ||||||
Compositional bias | 82-107 | Polar residues | ||||
Sequence: NDCKARRTAATGTAAPTATPAAQESG |
Keywords
- Technical term