A0A3Q1N8J7 · A0A3Q1N8J7_BOVIN

  • Protein
    Acyl-coenzyme A diphosphatase NUDT19
  • Gene
    NUDT19
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates. Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.

Catalytic activity

  • (6Z)-octenoyl-CoA + H2O = S-(6Z-octenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • (9Z)-tetradecenoyl-CoA + H2O = S-(9Z-tetradecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.77 (UniProtKB | ENZYME | Rhea)
  • hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • hexanoyl-CoA + H2O = hexanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • malonyl-CoA + H2O = malonyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • succinyl-CoA + H2O = succinyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H+
    This reaction proceeds in the forward direction.
  • an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • choloyl-CoA + H2O = S-choloyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.
  • dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
    This reaction proceeds in the forward direction.

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acyl-coenzyme A diphosphatase NUDT19
  • EC number
  • Alternative names
    • Nucleoside diphosphate-linked moiety X motif 19

Gene names

    • Name
      NUDT19

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1N8J7

Proteomes

Organism-specific databases

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-262Nudix hydrolase

Sequence similarities

Belongs to the Nudix hydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    391
  • Mass (Da)
    43,665
  • Last updated
    2024-05-29 v2
  • Checksum
    FB51165493E306FC
MSVPVRAGPSSWRRAATLVLAAGWTRPVPAAASRPQPPAEGFRVLLLQRSASQGFLPGAQVFPGGVLEAADRSTDWLRLFAPHHGPPRFGLGRAPPQRAAFPVLPNVRPGAVDEDAAALPDDIAFRICAIRETFEEAGVLLLRPRDPRPPNQAPGCALAPPPALADWRARVRRDPRHFLSLCAQLDCTPDIWALHDWSVWITPFSRPGGRRFETTFFLCCLNEPPPVFPDLVEVVDCQWSSPSEAIERLISKEILLAPPQFYEIRRLGNFASLSDLHKFSLDRESEGTERWMPIILLTADGMIHLLPGDEMYLEDANFLENCMSTEKKTEEIMNEGKKFHRIVLYNSHNYGDYTDYSIHVTVLPKYKHVYPKSCVVVSKRADGGTSRWSSG

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1M899A0A3Q1M899_BOVINNUDT19421
E1BDS7E1BDS7_BOVINNUDT19289

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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