A0A3Q1N0A4 · A0A3Q1N0A4_BOVIN
- ProteinHistone deacetylase
- GeneHDAC7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1036 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Catalytic activity
- N6-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate
Features
Showing features for binding site, active site, site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | 14-3-3 protein binding | |
Molecular Function | chromatin binding | |
Molecular Function | DNA-binding transcription factor binding | |
Molecular Function | histone deacetylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein kinase C binding | |
Molecular Function | transcription corepressor activity | |
Biological Process | cell-cell junction assembly | |
Biological Process | negative regulation of interleukin-2 production | |
Biological Process | negative regulation of non-canonical NF-kappaB signal transduction | |
Biological Process | negative regulation of osteoblast differentiation | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of cell migration involved in sprouting angiogenesis | |
Biological Process | protein deacetylation | |
Biological Process | regulation of mRNA processing | |
Biological Process | vasculogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone deacetylase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A3Q1N0A4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 92-134 | Disordered | ||||
Sequence: QVSPAAPCSSPPIIGWPRPRADTPGPQPQPMDLRVGQRPPVEP | ||||||
Compositional bias | 101-117 | Pro residues | ||||
Sequence: SPPIIGWPRPRADTPGP | ||||||
Region | 265-368 | Disordered | ||||
Sequence: PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPVLGSEADGDRRTHATLGPRGPVLGNP | ||||||
Compositional bias | 315-339 | Polar residues | ||||
Sequence: LGDSSPSSSSTPASGCSSPNDSEHG | ||||||
Region | 427-457 | Disordered | ||||
Sequence: RPSGSGLHRPLSRTRSEPLPPSATTPSLLGP | ||||||
Compositional bias | 471-490 | Basic and acidic residues | ||||
Sequence: LIKRSAKPSEKPRLRQIPSA | ||||||
Region | 471-524 | Disordered | ||||
Sequence: LIKRSAKPSEKPRLRQIPSAEDLETDGGSVGPLRDDGLEHRESSHGQQEARGTV | ||||||
Compositional bias | 503-517 | Basic and acidic residues | ||||
Sequence: LRDDGLEHRESSHGQ | ||||||
Region | 552-596 | Disordered | ||||
Sequence: SVLLPLAPGSHRPLSRAQSSPAAPASLSTPEPASQARILPSSETP | ||||||
Compositional bias | 564-596 | Polar residues | ||||
Sequence: PLSRAQSSPAAPASLSTPEPASQARILPSSETP | ||||||
Domain | 625-943 | Histone deacetylase | ||||
Sequence: HPEHAGRIQSIWSRLLERGLRSQCESLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQGKASKILIVDWDVHHGNGTQQTFYQDPNVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPPPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAAL |
Sequence similarities
Belongs to the histone deacetylase family. HD type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,036
- Mass (Da)111,929
- Last updated2024-05-29 v2
- ChecksumECCA65E29F777A5F
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q1NGD6 | A0A3Q1NGD6_BOVIN | HDAC7 | 988 | ||
A0AAA9T6A2 | A0AAA9T6A2_BOVIN | HDAC7 | 986 | ||
A0A3Q1MXW3 | A0A3Q1MXW3_BOVIN | HDAC7 | 970 | ||
A0AAA9TGJ2 | A0AAA9TGJ2_BOVIN | HDAC7 | 958 | ||
F1N616 | F1N616_BOVIN | HDAC7 | 988 | ||
A0A3Q1MDL2 | A0A3Q1MDL2_BOVIN | HDAC7 | 969 | ||
A0A3Q1MDB6 | A0A3Q1MDB6_BOVIN | HDAC7 | 995 | ||
A0AAA9U2N9 | A0AAA9U2N9_BOVIN | HDAC7 | 999 | ||
A0A3Q1MPP6 | A0A3Q1MPP6_BOVIN | HDAC7 | 972 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 101-117 | Pro residues | ||||
Sequence: SPPIIGWPRPRADTPGP | ||||||
Compositional bias | 315-339 | Polar residues | ||||
Sequence: LGDSSPSSSSTPASGCSSPNDSEHG | ||||||
Compositional bias | 471-490 | Basic and acidic residues | ||||
Sequence: LIKRSAKPSEKPRLRQIPSA | ||||||
Compositional bias | 503-517 | Basic and acidic residues | ||||
Sequence: LRDDGLEHRESSHGQ | ||||||
Compositional bias | 564-596 | Polar residues | ||||
Sequence: PLSRAQSSPAAPASLSTPEPASQARILPSSETP |
Keywords
- Technical term