A0A3Q1N0A4 · A0A3Q1N0A4_BOVIN

  • Protein
    Histone deacetylase
  • Gene
    HDAC7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

Features

Showing features for binding site, active site, site.

110361002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site617Zn2+ (UniProtKB | ChEBI)
Binding site619Zn2+ (UniProtKB | ChEBI)
Binding site625Zn2+ (UniProtKB | ChEBI)
Binding site702Zn2+ (UniProtKB | ChEBI)
Active site754
Site927Contributes to catalysis

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Function14-3-3 protein binding
Molecular Functionchromatin binding
Molecular FunctionDNA-binding transcription factor binding
Molecular Functionhistone deacetylase activity
Molecular Functionmetal ion binding
Molecular Functionprotein kinase C binding
Molecular Functiontranscription corepressor activity
Biological Processcell-cell junction assembly
Biological Processnegative regulation of interleukin-2 production
Biological Processnegative regulation of non-canonical NF-kappaB signal transduction
Biological Processnegative regulation of osteoblast differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of cell migration involved in sprouting angiogenesis
Biological Processprotein deacetylation
Biological Processregulation of mRNA processing
Biological Processvasculogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase
  • EC number

Gene names

    • Name
      HDAC7

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1N0A4

Proteomes

Organism-specific databases

Subcellular Location

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region92-134Disordered
Compositional bias101-117Pro residues
Region265-368Disordered
Compositional bias315-339Polar residues
Region427-457Disordered
Compositional bias471-490Basic and acidic residues
Region471-524Disordered
Compositional bias503-517Basic and acidic residues
Region552-596Disordered
Compositional bias564-596Polar residues
Domain625-943Histone deacetylase

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,036
  • Mass (Da)
    111,929
  • Last updated
    2024-05-29 v2
  • Checksum
    ECCA65E29F777A5F
MIQIRSWNFPQARCAWGGVGGVRLGFLAGTGDSTRVPRPPAPPRVTAGWWAVRACAFERGGPSLRRVCVDDSAPGQHGCLLAAPVAREDGTQVSPAAPCSSPPIIGWPRPRADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQHPQRLHHHLFLAGLQPQRSAEPMRLSMDTPMPELQMGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPSVPYRTLEPLETEGAARSMLSSFLPPVPSLPCDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPVLGSEADGDRRTHATLGPRGPVLGNPHAHLFLPHGLEPEAGGPLPSRLQPILLLDPSVTHTPLLTVPGLGPLPFHFAQSLLTTERPSGSGLHRPLSRTRSEPLPPSATTPSLLGPLQPRLERLKPHVQLIKRSAKPSEKPRLRQIPSAEDLETDGGSVGPLRDDGLEHRESSHGQQEARGTVPLQQHQQVFLWEQQRLAGRLPRGATGDSVLLPLAPGSHRPLSRAQSSPAAPASLSTPEPASQARILPSSETPARTLPFTTGLVYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLLERGLRSQCESLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQGKASKILIVDWDVHHGNGTQQTFYQDPNVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPPPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLGNKVDPLSEEGWKQKPNLNAIRSLEAVIRVHSEYWGCMQRLASRPDSWVHRVPGADAEEVEAVTALASLSVGILAEERTSGQLVEEEEPMNL

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1NGD6A0A3Q1NGD6_BOVINHDAC7988
A0AAA9T6A2A0AAA9T6A2_BOVINHDAC7986
A0A3Q1MXW3A0A3Q1MXW3_BOVINHDAC7970
A0AAA9TGJ2A0AAA9TGJ2_BOVINHDAC7958
F1N616F1N616_BOVINHDAC7988
A0A3Q1MDL2A0A3Q1MDL2_BOVINHDAC7969
A0A3Q1MDB6A0A3Q1MDB6_BOVINHDAC7995
A0AAA9U2N9A0AAA9U2N9_BOVINHDAC7999
A0A3Q1MPP6A0A3Q1MPP6_BOVINHDAC7972

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias101-117Pro residues
Compositional bias315-339Polar residues
Compositional bias471-490Basic and acidic residues
Compositional bias503-517Basic and acidic residues
Compositional bias564-596Polar residues

Keywords

Genome annotation databases

Similar Proteins

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